Evidence map›Paper›PMID 39207622›Full record

ArticleNeuroscience bulletin2025

The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice.

Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi and 3 more

Abstract read
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Histamine HMolecular psychiatry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiabin FengDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.
Xiaojun WangDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.
Meidie PanLiangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, 311121, China.
Chen-Xi LiDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.
Zhe ZhangDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.
Meng SunDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.
Tailin LiaoLiangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, 311121, China.
Ziyi WangInnovative Institute of Basic Medical Sciences of Zhejiang University (Yuhang), Hangzhou, 310058, China.
Jianhong LuoDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China.ORCID http://orcid.org/0000-0001-7832-496X
Lei ShiJNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, 510632, China.
Yu-Jing ChenDepartment of Traditional Chinese Medicine, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. tcmcyj@163.com.
Hai-Feng LiDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China. 6199005@zju.edu.cn.
Junyu XuDepartment of Rehabilitation of Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, China. junyuxu@hkust-gz.edu.cn.ORCID http://orcid.org/0000-0002-1911-3553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety disorder is a major symptom of autism spectrum disorder (ASD) with a comorbidity rate of ~40%. However, the neural mechanisms of the emergence of anxiety in ASD remain unclear. In our study, we found that hyperactivity of basolateral amygdala (BLA) pyramidal neurons (PNs) in Shank3 InsG3680 knock-in (InsG3680

Indexed as

AnxietyBasolateral Nuclear ComplexNerve Tissue ProteinsPrefrontal CortexAnimalsGene Knock-In TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMicrofilament ProteinsNeural PathwaysPyramidal CellsMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouseAnxietyAutism spectrum disorderBasolateral amygdalaMedial prefrontal cortex

Identifiers

PMID39207622
PMCPMC11748662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.