Evidence map›Paper›PMID 39207499›Full record

ReviewApplied microbiology and biotechnology2024

Synthetic biology toolkit of Ralstonia eutropha (Cupriavidus necator).

Lara Santolin, Sebastian L Riedel, Christopher J Brigham

Abstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Pressure Dependent Changes in COBiotechnology journal · 2026
    Article
  3. Article
  4. Solar Air-to-Fuel Technologies for a Circular Carbon Economy.Journal of the American Chemical Society · 2026
    Review
  5. Article
  6. Review
  7. Polyhydroxyalkanoate production from food residues.Applied microbiology and biotechnology · 2025
    Review
  8. Review
  9. A promoter library for tuning gene expression inFrontiers in bioengineering and biotechnology · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lara SantolinTechnische Universität Berlin, Institute of Biotechnology, Chair of Bioprocess Engineering, Berlin, Germany.
Sebastian L RiedelBerliner Hochschule Für Technik, Department VIII - Mechanical Engineering, Event Technology and Process Engineering, Environmental and Bioprocess Engineering Laboratory, Berlin, Germany. Sebastian.Riedel@bht-berlin.de.ORCID http://orcid.org/0000-0003-1373-417X
Christopher J BrighamDepartment of Bioengineering, University of Massachusetts Dartmouth, North Dartmouth, MA, USA. cbrigham@umassd.edu.

Funding

Bundesministerium für Bildung und Forschung 031B1339A
6 · The paper itself

Abstract

Synthetic biology encompasses many kinds of ideas and techniques with the common theme of creating something novel. The industrially relevant microorganism, Ralstonia eutropha (also known as Cupriavidus necator), has long been a subject of metabolic engineering efforts to either enhance a product it naturally makes (polyhydroxyalkanoate) or produce novel bioproducts (e.g., biofuels and other small molecule compounds). Given the metabolic versatility of R. eutropha and the existence of multiple molecular genetic tools and techniques for the organism, development of a synthetic biology toolkit is underway. This toolkit will allow for novel, user-friendly design that can impart new capabilities to R. eutropha strains to be used for novel application. This article reviews the different synthetic biology techniques currently available for modifying and enhancing bioproduction in R. eutropha. KEY POINTS: • R. eutropha (C. necator) is a versatile organism that has been examined for many applications. • Synthetic biology is being used to design more powerful strains for bioproduction. • A diverse synthetic biology toolkit is being developed to enhance R. eutropha's capabilities.

Indexed as

Cupriavidus necatorMetabolic EngineeringSynthetic BiologyBiofuelsPolyhydroxyalkanoatesBiofuelsPolyhydroxyalkanoatesBioproductionIndustrial biotechnologyMetabolic engineeringRalstonia eutropha (Cupriavidus necator)Standardized partsSynthetic biology toolkit

Identifiers

PMID39207499
PMCPMC11362209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.