New robust and efficient liquid membranes for conductive vial electromembrane extraction of acids with low to moderate hydrophilicity in human plasma.

Chenchen Song, Samira Dowlatshah, Somayeh Gaznawi, Anne Oldeide Hay, Grete Hasvold, Frederik André Hansen

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Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Chenchen SongDepartment of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway.

Samira DowlatshahDepartment of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway.

Somayeh GaznawiDepartment of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway.

Anne Oldeide HayDepartment of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway.

Grete HasvoldDepartment of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway.

Frederik André HansenDepartment of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway. f.a.hansen@farmasi.uio.no.ORCID http://orcid.org/0000-0002-1666-0447

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current paper reports two new, robust, and efficient conditions for electromembrane extraction of acidic substances from human plasma. Two systems were developed based on eutectic solvents: A1 ("A" for acid) comprised dodecyl methyl sulfoxide and thymol in 1:2 ratio (w/w) as liquid membrane, while A2 used [6-methylcoumarin:thymol (1:2)]:2-nitrophenyl octyl ether in 2:1 ratio (w/w). The performance of A1 and A2 was characterized by extraction of 31 acidic model analytes (pharmaceutical drugs and nutrients) spiked into 100 µL human plasma diluted 1:1 (v/v) with phosphate buffer pH 7.4. The acceptor solution was 50 mM NH

Indexed as

AcidsElectrochemical TechniquesMembranes, ArtificialHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsLimit of DetectionPharmaceutical PreparationsReproducibility of ResultsAcidsMembranes, ArtificialPharmaceutical PreparationsAcidic analytesElectromembrane extractionMicroextractionNew liquid membranesSample preparation

Identifiers

PMID39207493

DOI10.1007/s00216-024-05503-6

PMCPMC11861104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.