Evidence map›Paper›PMID 39207487›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction.

Kentaro Otani, Tsutomu Zeniya, Hidekazu Kawashima, Tetsuaki Moriguchi, Atsushi Nakano, Chunlei Han, Shunsuke Murata, Kunihiro Nishimura, Kazuhiro Koshino, Kenichi Yamahara and 2 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kentaro OtaniDepartment of Molecular Pharmacology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.ORCID 0000-0001-7607-8056
Tsutomu ZeniyaGraduate School of Science and Technology, Hirosaki University, Aomori, Japan.
Hidekazu KawashimaRadioisotope Research Center, Kyoto Pharmaceutical University, Kyoto, Japan.
Tetsuaki MoriguchiTandem Accelerator Complex (UTTAC), University of Tsukuba, Ibaraki, Japan.
Atsushi NakanoDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Chunlei HanTurku PET Centre, Turku University Hospital, Turku, Finland.
Shunsuke MurataDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Kunihiro NishimuraDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Kazuhiro KoshinoDepartment of Systems and Informatics, Hokkaido Information University, Hokkaido, Japan.
Kenichi YamaharaLaboratory of Molecular and Cellular Therapy, Institute for Advanced Medical Sciences, Hyogo Medical University, Hyogo, Japan.
Masayuki InubushiDivision of Nuclear Medicine, Department of Radiology, Kawasaki Medical School, Okayama, Japan.
Hidehiro IidaTurku PET Centre, Turku University Hospital, Turku, Finland. hidehiro.iida@utu.fi.ORCID 0000-0002-7914-3068

Funding

Japan Agency for Medical Research and Development 15jm0310001Japan Agency for Medical Research and Development JP19mk0101099Japan Cardiovascular Research Foundation 12-003Japan Society for the Promotion of Science JP29293282
6 · The paper itself

Abstract

purposeThis study aimed to evaluate a novel technique for cell tracking by visualising the activity of the human sodium/iodide symporter (hNIS) after transplantation of hNIS-expressing multilayered cell sheets in a rat model of chronic myocardial infarction.

methodsTriple-layered cell sheets were generated from mouse embryonic fibroblasts (MEFs) derived from mice overexpressing hNIS (hNIS-Tg). Myocardial infarction was induced by permanent ligation of the left anterior descending coronary artery in F344 athymic rats, and a triple-layered MEFs sheets were transplanted to the infarcted area two weeks after surgery. To validate the temporal tracking and kinetic analysis of the transplanted MEFs sheets, sequential cardiac single-photon emission computed tomography (SPECT) examinations with a

resultsA significantly higher amount of

conclusionThe reporter gene imaging with hNIS enables the serial tracking and quantitative kinetic analysis of cell sheets transplanted to infarcted hearts.

Indexed as

Cell TrackingGenes, ReporterMyocardial InfarctionSymportersTomography, Emission-Computed, Single-PhotonAnimalsDisease Models, AnimalFibroblastsHumansMaleMiceRatsRats, Inbred F344Sodium-Iodide SymportersSodium-Iodide SymportersSymportersCells sheetMouse embryonic fibroblastMyocardial infarctionReporter imagingSPECT

Identifiers

PMID39207487
PMCPMC11599416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.