Evidence map›Paper›PMID 39207203›Full record

ArticleACS chemical neuroscience2024

Insights into Vincristine-Induced Peripheral Neuropathy in Aged Rats: Wallerian Degeneration, Oxidative Damage, and Alterations in ATPase Enzymes.

Ketlyn P da Motta, Carolina C Martins, Vanessa M E da Rocha, Mauro P Soares, Marcia F Mesko, Cristiane Luchese, Ethel A Wilhelm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ketlyn P da MottaPostgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Box 354, CEP, 96010-900 Pelotas, RS, Brazil.
Carolina C MartinsPostgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Box 354, CEP, 96010-900 Pelotas, RS, Brazil.
Vanessa M E da RochaPostgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Box 354, CEP, 96010-900 Pelotas, RS, Brazil.
Mauro P SoaresRegional Diagnostic Laboratory Faculty of Veterinary Medicine, Federal University of Pelotas (UFPel), CEP, 96010-900 Pelotas, RS, Brazil.
Marcia F MeskoContaminant Control Laboratory in Biomaterials (LCCBio), Federal University of Pelotas (UFPel), CEP, 96010-900 Pelotas, RS, Brazil.ORCID 0000-0002-7399-446X
Cristiane LuchesePostgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Box 354, CEP, 96010-900 Pelotas, RS, Brazil.
Ethel A WilhelmPostgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Box 354, CEP, 96010-900 Pelotas, RS, Brazil.ORCID 0000-0002-2875-9962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to elucidate vincristine (VCR)-induced peripheral neuropathy in aged rats, a poorly understood neurotoxicity. Both young and old Wistar rats were administered VCR (0.1 mg/kg, intraperitoneally (i.p.)) and compared to age-matched controls (0.9% saline; 10 mg/mL, i.p.). Mechanical (MN) and thermal nociceptive (TN) responses were assessed on days 0, 6, 11, and 17. Locomotor response, cognitive ability, and anxious-like behavior were evaluated on days 14, 15, and 16. Results showed MN and TN responses in both young and old VCR-exposed rats. In old rats, VCR exacerbated MN (on days 6, 11, and 17) and TN (on days 6 and 17) responses. VCR also induced cognitive impairments and anxiety-like behavior. Histological analysis revealed Wallerian degeneration in the spinal cords of VCR-exposed rats accompanied by macrophage migration. Furthermore, VCR increased Ca

Indexed as

Adenosine TriphosphatasesAgingOxidative StressPeripheral Nervous System DiseasesRats, WistarVincristineWallerian DegenerationAnimalsAntineoplastic Agents, PhytogenicLipid PeroxidationMaleRatsSodium-Potassium-Exchanging ATPaseSpinal CordAdenosine TriphosphatasesAntineoplastic Agents, PhytogenicSodium-Potassium-Exchanging ATPaseVincristineCa2+-ATPaselipoperoxidationneuropathy in the oldvincristineWallerian degeneration

Identifiers

PMID39207203
PMCPMC11587511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.