ArticleJournal of magnetic resonance imaging : JMRI2025
Quantitative Analysis of Small Intestinal Motility in 3D Cine-MRI Using Centerline-Aware Motion Estimation.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Temporal AI-assisted compressed sensing for high-resolution, motion-robust small-bowel MR enterography without antiperistaltic agents: a feasibility study.European radiology · 2026Article
- Unified NDMI for small intestinal cine MRI: repeatability and sensitivity to multicenter variability.Abdominal radiology (New York) · 2026Article
- Quantitative Real-Time MRI for the Assessment of Gastric Motility.Journal of magnetic resonance imaging : JMRI · 2026Article
- Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging.Journal of magnetic resonance imaging : JMRI · 2026Review
- The Evolving Role of Cine MRI in Crohn's Disease: From Functional Motility Analysis to Precision Management: A Review of the Last 10 Years.Diagnostics (Basel, Switzerland) · 2025Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently available tools for noninvasive motility quantification of the small intestine are limited to dynamic 2D MRI scans, which are limited in their ability to differentiate between types of intestinal motility. PURPOSE: To develop a method for quantification and characterization of small intestinal motility in 3D, capable of differentiating motile, non-motile and peristaltic motion patterns. STUDY TYPE: Prospective. SUBJECTS: Fourteen healthy volunteers (127 small intestinal segments) and 10 patients with Crohn's disease (87 small intestinal segments). FIELD STRENGTH/SEQUENCE: 3.0 T, 3D balanced fast field echo sequence, 1 volume per second. ASSESSMENT: Using deformable image registration between subsequent volumes, the local velocity within the intestinal lumen was quantified. Average velocity and average absolute velocity along intestinal segments were used with linear classifiers to differentiate motile from non-motile intestines, as well as erratic motility from peristalsis. The mean absolute velocity of small intestinal content was compared between healthy volunteers and Crohn's disease patients, and the discriminative power of the proposed motility metrics for detecting motility and peristalsis was determined. The consensus of two observers was used as referenced standard. STATISTICAL TESTS: Student's t-test to assess differences between groups; area under the receiver operating characteristic curve (AUC) to assess discriminative ability. P < 0.001 was considered significant.
resultsA significant difference in the absolute velocity of intestinal content between Crohn's patients and healthy volunteers was observed (median [IQR] 1.06 [0.61, 1.56] mm/s vs. 1.84 [1.37, 2.43] mm/s), which was consistent with manual reference annotations of motile activity. The proposed method had a strong discriminative performance for detecting non-motile intestines (AUC 0.97) and discernible peristalsis (AUC 0.81). DATA
conclusionAnalysis of 3D cine-MRI using centerline-aware motion estimation has the potential to allow noninvasive characterization of small intestinal motility and peristaltic motion in 3D. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 2.
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