ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Motor versus Psychomotor? Deciphering the Neural Source of Psychomotor Retardation in Depression.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment.Human brain mapping · 2026Article
- Dynamics of thoughts-novel candidate marker for differential-diagnosis of mental disorders?Journal of psychiatry & neuroscience : JPN · 2026Review
- Same movies, different stories: aberrant brain state dynamics during naturalistic emotional stimuli in depression.Journal of translational medicine · 2025Article
- Visuomotor dysconnectivity as a candidate mechanism of psychomotor agitation in major depression.Psychological medicine · 2025Article
- Automatic quantification of hand gestures in current and remitted Major Depressive Disorder during oral expression.Journal of affective disorders · 2025Article
- Reduced neural suppression at occipital cortex in subthreshold depression.Translational psychiatry · 2025Article
- Aberrant functional connectivity and the intrinsic activity of primary visual network and their relationship with adolescent atypical depression symptoms.Frontiers in psychiatry · 2025Article
- Altered static and dynamic functional connectivity in major depressive disorder accompanied by high anxiety: evidence from the REST-meta-MDD consortium.Frontiers in psychiatry · 2025Article
- Motor versus Psychomotor? Deciphering the Neural Source of Psychomotor Retardation in Depression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Beyond mood - depression as a speed disorder: biomarkers for abnormal slowness.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Major depressive disorder (MDD) is characterized by psychomotor retardation whose underlying neural source remains unclear. Psychomotor retardation may either be related to a motor source like the motor cortex or, alternatively, to a psychomotor source with neural changes outside motor regions, like input regions such as visual cortex. These two alternative hypotheses in main (n = 41) and replication (n = 18) MDD samples using 7 Tesla MRI are investigated. Analyzing both global and local connectivity in primary motor cortex (BA4), motor network and middle temporal visual cortex complex (MT+), the main findings in MDD are: 1) Reduced local and global synchronization and increased local-to-global output in motor regions, which do not correlate with psychomotor retardation, though. 2) Reduced local-to-local BA4 - MT+ functional connectivity (FC) which correlates with psychomotor retardation. 3) Reduced global synchronization and increased local-to-global output in MT+ which relate to psychomotor retardation. 4) Reduced variability in the psychophysical measures of MT+ based motion perception which relates to psychomotor retardation. Together, it is shown that visual cortex MT+ and its relation to motor cortex play a key role in mediating psychomotor retardation. This supports psychomotor over motor hypothesis about the neural source of psychomotor retardation in MDD.
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