Evidence map›Paper›PMID 39207051›Full record

ArticlePharmacology research & perspectives2024

IS4-FAM, a fluorescent tool to study CXCR4 affinity and competitive antagonism in native cancer cells.

Isabel Hamshaw, Marco M D Cominetti, Princess Nana-Akyin, Ernie Ho Yee Ho, Mark Searcey, Anja Mueller

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabel HamshawSchool of Pharmacy, University of East Anglia, Norwich, UK.
Marco M D CominettiSchool of Pharmacy, University of East Anglia, Norwich, UK.
Princess Nana-AkyinSchool of Pharmacy, University of East Anglia, Norwich, UK.
Ernie Ho Yee HoSchool of Pharmacy, University of East Anglia, Norwich, UK.
Mark SearceySchool of Pharmacy, University of East Anglia, Norwich, UK.
Anja MuellerSchool of Pharmacy, University of East Anglia, Norwich, UK.ORCID 0000-0003-0774-0434

Funding

UKRI Biotechnology and Biological Sciences Research Council Norwich Research Park Biosciences Doctoral Training Partnership BB/T008717/1Wellcome Trust
6 · The paper itself

Abstract

The ability to accurately measure drug-target interaction is critical for the discovery of new therapeutics. Classical pharmacological bioassays such as radioligand or fluorescent ligand binding assays can define the affinity or K

Indexed as

Fluorescent DyesReceptors, CXCR4Binding, CompetitiveCell Line, TumorFlow CytometryHumansMicroscopy, ConfocalNeoplasmsPC-3 CellsCXCR4 protein, humanFluorescent DyesReceptors, CXCR4antagonistchemokine receptorCXCL12CXCR4

Identifiers

PMID39207051
PMCPMC11359705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.