Evidence map›Paper›PMID 39206814›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Blocking ACSL6 Compromises Autophagy via FLI1-Mediated Downregulation of COLs to Radiosensitize Lung Cancer.

Wen Ding, Shijun Bao, Qingwei Zhao, Wei Hao, Kai Fang, Yanlan Xiao, Xiaoting Lin, Zhemeng Zhao, Xinyi Xu, Xinyue Cui and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wen DingDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Shijun BaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Qingwei ZhaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Wei HaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Kai FangDepartment of Medicine College, Jiangnan University, Wuxi, Jiangsu, 214000, P. R. China.
Yanlan XiaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Xiaoting LinDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Zhemeng ZhaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Xinyi XuDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Xinyue CuiDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Xiwen YangDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Liuhuan YaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.
Hai JinDepartment of Cardiothoracic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, P. R. China.
Kun ZhangDepartment of Laboratory Medicine and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu, Sichuan, 610072, P. R. China.
Jiaming GuoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, P. R. China.ORCID 0000-0001-9898-237X

Funding

National Natural Science Foundation of China 31900890Sailing Talent Project Program of the Naval Medical UniversityShanghai Sailing Program 19YF1459000
6 · The paper itself

Abstract

Lung cancer (LC) is the leading cause of cancer-related mortality worldwide. Radiotherapy is the main component of LC treatment; however, its efficacy is often limited by radioresistance development, resulting in unsatisfactory clinical outcomes. Here, we found that LC radiosensitivity is up-regulated by decreased expression of long-chain acyl-CoA synthase 6 (ACSL6) after irradiation. Deletion of ACSL6 results in significant elevation of Friend leukemia integration 1 transcription factor (FLI1) and a marked decline of collagens (COLs). Blocking of ACSL6 impairs the tumor growth and upregulates FLI1, which reduces the levels of COLs and compromises irradiation-induced autophagy, leading to considerable therapeutic benefits during radiotherapy. Moreover, the direct interaction between ACSL6 and FLI1 and engagement between FLI1 and COLs indicates the involvement of the ACSL6-FLI1-COL axis. Finally, the potently adjusted autophagy flux reduces its otherwise contributive capability in surviving irradiation stress and leads to satisfactory radiosensitization for LC radiotherapy. These results demonstrate that enhanced ACSL6 expression promotes the aggressive performance of irradiated LC through increased FLI1-COL-mediated autophagy flux. Thus, the ACSL6-FLI1-Col-autophagy axis may be targeted to enhance the radiosensitivity of LC and improve the management of LC in radiotherapy.

Indexed as

AutophagyCoenzyme A LigasesDown-RegulationLung NeoplasmsProto-Oncogene Protein c-fli-1AnimalsCell Line, TumorDisease Models, AnimalHumansLong-Chain-Fatty-Acid-CoA LigaseMiceRadiation ToleranceCoenzyme A LigasesFLI1 protein, humanLong-Chain-Fatty-Acid-CoA LigaseProto-Oncogene Protein c-fli-1autophagycollagenFLI1long‐chain Acyl‐CoA Synthase 6lung cancerradiosensitivityradiotherapy

Identifiers

PMID39206814
PMCPMC11516120

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.