Evidence map›Paper›PMID 39206632›Full record

ArticleThe FEBS journal2025

Altered O-glycosylation of β

Hanna E Tuhkanen, Ilona J Haasiomäki, Jarkko J Lackman, Christoffer K Goth, S Orvokki Mattila, Zilu Ye, Sergey Y Vakhrushev, Johanna Magga, Risto Kerkelä, Henrik Clausen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Association of FunctionalInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hanna E TuhkanenMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.
Ilona J HaasiomäkiMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.
Jarkko J LackmanMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.
Christoffer K GothCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
S Orvokki MattilaMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.
Zilu YeCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Sergey Y VakhrushevCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Johanna MaggaMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.ORCID 0000-0003-4688-9098
Risto KerkeläMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.
Henrik ClausenCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Katrine T SchjoldagerCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Ulla E Petäjä-RepoMedical Research Center Oulu and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland.ORCID 0000-0003-1141-2150

Funding

Aarne Koskelon SäätiöDanish Research Council 10.46540/2066-00043BMagnus Ehrnrooth FoundationNovo Nordisk Fonden NNF22OC0073793Paavo Nurmen SäätiöSuomen KulttuurirahastoSydäntutkimussäätiöTerveyden Tutkimuksen Toimikunta 295140Terveyden Tutkimuksen Toimikunta 338736
6 · The paper itself

Abstract

N-terminal nonsynonymous single-nucleotide polymorphisms (SNPs) of G protein-coupled receptors (GPCRs) are common and often affect receptor post-translational modifications. Their functional implications are, however, largely unknown. We have previously shown that the human β

Indexed as

Polymorphism, Single NucleotideReceptors, Adrenergic, beta-1AnimalsGlycosylationHEK293 CellsHumansIsoproterenolMyocytes, CardiacProtein Processing, Post-TranslationalProteolysisRatsADRB1 protein, humanIsoproterenolReceptors, Adrenergic, beta-1G protein‐coupled receptorO‐glycosylationproteolytic processingsingle‐nucleotide polymorphismβ1‐adrenergic receptor

Identifiers

PMID39206632
PMCPMC11880984

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.