Evidence map›Paper›PMID 39206549›Full record

Trial reportCirculation2024

Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial.

Andrew P DeFilippis, J Dawn Abbott, Brandon M Herbert, Marnie H Bertolet, Bernard R Chaitman, Harvey D White, Andrew M Goldsweig, Tamar S Polonsky, Rajesh Gupta, Caroline Alsweiler and 14 more

Registry-linked trialAbstract readRandomized Controlled TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02981407 (Myocardial Ischemia and Transfusion), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02981407 phase3completednot on this map

Myocardial Ischemia and Transfusion

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2017 to 2023Enrolled3,506ConditionsMyocardial Infarction, AnemiaArmsRed Blood Cell Transfusion
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Defining myocardial infarction: grades of severity or different aetiology.European heart journal. Acute cardiovascular care · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Andrew P DeFilippisDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (A.P.D.).ORCID 0000-0002-5135-9748
J Dawn AbbottLifespan Cardiovascular Institute and Department of Medicine, Division of Cardiology, Alpert Medical School of Warren Alpert Medical School. Brown University, Providence, RI (J.D.A.).ORCID 0000-0002-2560-0155
Brandon M HerbertUniversity of Pittsburgh School of Public Health, PA (B.M.H., M.H.B., M.M.B.).ORCID 0000-0003-3857-7422
Marnie H BertoletUniversity of Pittsburgh School of Public Health, PA (B.M.H., M.H.B., M.M.B.).ORCID 0000-0002-5799-9033
Bernard R ChaitmanSt Louis University School of Medicine, MO (B.R.C.).ORCID 0000-0002-9216-5317
Harvey D WhiteGreen Lane Coordinating Center, Auckland, New Zealand (H.D.W., C.A.).ORCID 0000-0001-7712-6750
Andrew M GoldsweigDepartment of Medicine, Baystate Medical Center, Springfield, MA (A.M.G.).ORCID 0000-0003-2952-7837
Tamar S PolonskyDepartment of Medicine, University of Chicago Medicine, IL (T.S.P.M.T.).ORCID 0000-0003-2112-9244
Rajesh GuptaDepartment of Medicine, Division of Cardiovascular Medicine, University of Toledo, OH (R.G.).ORCID 0000-0001-7428-7671
Caroline AlsweilerGreen Lane Coordinating Center, Auckland, New Zealand (H.D.W., C.A.).ORCID 0009-0004-9463-0165
Johanne SilvainSorbonne Université, ACTION Study Group, INSERM UMRS1166, Institut de Cardiologie Hôpital Pitié-Salpêtrière (AP-HP), Paris, France (J.S.).ORCID 0000-0002-1901-2808
Pedro G M de Barros E SilvaBrazilian Clinical Research Institute, Sao Paulo (P.G.M.dBeS.).ORCID 0000-0003-1940-4470
Graham S HillisDepartment of Cardiology, Royal Perth Hospital and Medical School, University of Western Australia, Perth (G.S.H.).ORCID 0000-0003-2417-4673
Benoit DaneaultCentre Hospitalier Universitaire de Sherbrooke, QC, Canada (B.D.).
Meechai TessaleeDepartment of Medicine, University of Chicago Medicine, IL (T.S.P.M.T.).
Mark A MenegusDivision of Cardiology, Montefiore Medical Center, NY (M.A.M.).
Sunil V RaoNew York University Langone Health System, NY (S.V.R., J.H.A.).ORCID 0000-0003-2914-0894
Renato D LopesDuke Clinical Research Institute, Division of Cardiology, Duke University, Durham, NC (R.D.L.).ORCID 0000-0003-2999-4961
Paul C HébertBruyere Research Institute, University of Ottawa, Canada (P.C.H.).ORCID 0000-0002-0440-8586
John H AlexanderNew York University Langone Health System, NY (S.V.R., J.H.A.).ORCID 0000-0002-1444-2462
Maria M BrooksUniversity of Pittsburgh School of Public Health, PA (B.M.H., M.H.B., M.M.B.).ORCID 0000-0002-2030-7873
Jeffrey L CarsonRutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.).ORCID 0000-0001-5466-2833
Shaun G GoodmanSt Michael's Hospital, Unity Health Toronto and Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto (S.G.G.).ORCID 0000-0001-8068-2440
MINT Investigators

Funding

Myocardial Ischemia and Transfusion (MINT) - CCCU01HL133817 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CARSON, JEFFREY LEE · 2016 to 2022
$17.1M
Myocardial Ischemia and Transfusion (MINT) - DCCU01HL132853 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 2016 to 2022
$4.1M
NHLBI NIH HHS U01 HL132853NHLBI NIH HHS U01 HL133817
6 · The paper itself

Abstract

backgroundThe MINT trial (Myocardial Ischemia and Transfusion) raised concern for harm from a restrictive versus liberal transfusion strategy in patients with acute myocardial infarction (MI) and anemia. Type 1 and type 2 MI are distinct pathophysiologic entities that may respond differently to blood transfusion. This analysis sought to determine whether the effects of transfusion varied among patients with a type 1 or a type 2 MI and anemia. The authors hypothesized that the liberal transfusion strategy would be of greater benefit in type 2 than in type 1 MI.

methodsThe authors compared rates of death or MI at 30 days in patients with type 1 (n=1460) and type 2 (n=1955) MI and anemia who were randomly allocated to a restrictive (threshold, 7-8 g/dL) or a liberal (threshold, 10 g/dL) transfusion strategy.

resultsThe primary outcome of death or MI was observed in 16% of type 1 MI and 15.4% of type 2 MI patients. The rate of death or MI was higher in patients with type 1 MI randomized to a restrictive (18.2%) versus liberal (13.8%) transfusion strategy (relative risk [RR], 1.32 [95% CI, 1.04-1.67]) with no difference observed between the restrictive (15.8%) and liberal (15.1%) transfusion strategies in patients with type 2 MI (RR, 1.05 [95% CI, 0.85-1.29]). The test for a differential effect of transfusion strategy by MI type was not statistically significant (

conclusionsThe concern for harm with a restrictive transfusion strategy in patients with acute MI and anemia raised in the MINT primary outcome manuscript may be more apparent in patients with type 1 than type 2 MI. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02981407.

Indexed as

AnemiaBlood TransfusionMyocardial InfarctionAgedFemaleHumansMaleMiddle AgedTreatment Outcomeacute coronary syndromeblood transfusionclinical trials as topicmyocardial infarction

Identifiers

PMID39206549
PMCPMC11611643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.