Article in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Naoki KiyotaFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.ORCID 0000-0003-4613-7048
Tuncer OnayFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.ORCID 0000-0001-8891-2300
Phoebe LeeawFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.ORCID 0009-0009-0530-0153
Pan LiuFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.ORCID 0000-0002-3066-652X
Dilip K DebFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.
Benjamin R ThomsonFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.ORCID 0000-0001-6565-5866
Ayellet V SegrèDepartment of Ophthalmology, Ocular Genomics Institute, Massachusetts Eye and Ear, Boston (A.V.S., J.L.W.).ORCID 0000-0001-6806-5845
Janey L WiggsDepartment of Ophthalmology, Ocular Genomics Institute, Massachusetts Eye and Ear, Boston (A.V.S., J.L.W.).ORCID 0000-0003-1890-3278
Susan E QuagginFeinberg Cardiovascular and Renal Research Institute (N.K., T.O., P. Leeaw, P. Liu, D.K.D., B.R.T., S.E.Q.), Northwestern University Feinberg School of Medicine, Chicago.ORCID 0000-0002-3706-5727
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Activation of the Angiopoietin-Tie2/TEK Pathway to Treat Ocular Hypertension and GlaucomaR01EY025799 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JIN, JING, QUAGGIN, SUSAN E. · 2016 to 2024
$5.8M
Therapeutics Development Core (Core B)P30DK114857 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QUAGGIN, SUSAN E. · 2018 to 2022
$5.7M
The role of Angiopoietin-TEK signaling in polypoidal choroidal vasculopathyR01EY032609 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THOMSON, BENJAMIN R. · 2021 to 2025
backgroundThe ANGPT (angiopoietin)-TEK (tyrosine kinase, endothelial) vascular signaling pathway plays a key role in the formation of Schlemm canal, and loss-of-function mutations in the
methodsMT (mutant) mice harboring an orthologous rs76020419 minor allele (T) were generated using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated 9). Plasma and tissue samples, including eyes, were collected, and ANGPT2 expression was quantified using ELISA. Anterior segments from eyes were collected from WT (wild-type) and MT mice, and Schlemm canal area was quantified.
resultsIn the MT group, higher ANGPT2 concentrations were observed in the plasma, lungs, kidneys, and eyes (
conclusionsThe rs76020419 minor allele (T) is associated with increased levels of ANGPT2 and a larger Schlemm canal in mice. These findings suggest a potential protective mechanism in glaucoma.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Glaucoma-Protective Human Single-Nucleotide Polymorphism in the · full record | OpenQuestion