Evidence map›Paper›PMID 39206479›Full record

ReviewCurrent medicinal chemistry2025

The Role of Redox Environment in Tumors.

Jiaping Wu, Liling Hu, Wei Liu, Xiaowen Liu, Jun Zheng, Xiao Tan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiaping WuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.
Liling HuThe First College of Clinical Medical Science, China Three Gorges University, Yichang, 443002, China.
Wei LiuThe First College of Clinical Medical Science, China Three Gorges University, Yichang, 443002, China.
Xiaowen LiuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.
Jun ZhengThe First College of Clinical Medical Science, China Three Gorges University, Yichang, 443002, China.
Xiao TanHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.

Funding

Application Fund of China Three Gorges University SDHZ2021245, SDHZ20230118National Natural Science Foundation of China 81602743Open Fund of Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University 2023KZL02
6 · The paper itself

Abstract

Reactive Oxygen Species (ROS) and the redoxin system regulate the redox environment. Thus, they mediate various physiological and pathological processes involved in tumor occurrence and development by activating redox-sensitive genes and regulating redox signaling pathways, including tumor cell proliferation, migration, invasion, and various cell death types. Therefore, the mechanism underlying redox environment regulation must be clarified to accurately target this mechanism and improve the effect of tumor treatment. This review introduces redox-sensitive transcription factors and their activated downstream signaling pathways, and the application of inhibitors targeting related transcription factors in tumor therapy.

Indexed as

NeoplasmsReactive Oxygen SpeciesAnimalsAntineoplastic AgentsHumansOxidation-ReductionSignal TransductionTranscription FactorsAntineoplastic AgentsReactive Oxygen SpeciesTranscription Factorscarcinogensdefense systemglutathione.Redox environmenttargeted therapeutic inhibitorstumor

Identifiers

PMID39206479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.