ArticlePhysics and imaging in radiation oncology2024
Balancing benefits and limitations of linear energy transfer optimization in carbon ion radiotherapy for large sacral chordomas.
Article in Physics and imaging in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment.Magnetic resonance in medicine · 2026Article
- Evaluation of crizotinib as radiosensitizer in sacral chordoma cells: effects of combined carbon ion particle therapy.Medical oncology (Northwood, London, England) · 2025Article
- Microstructural modelling based on diffusion weighted imaging to guide dose painting in carbon ions for large sacral chordomas.Physics and imaging in radiation oncology · 2025Article
- Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept.Physics and imaging in radiation oncology · 2024Article
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Authors and funding
11 authors.
Funding
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Abstract
Background and Purpose: A low linear energy transfer (LET) in the target can reduce the effectiveness of carbon ion radiotherapy (CIRT). This study aimed at exploring benefits and limitations of LET optimization for large sacral chordomas (SC) undergoing CIRT. Materials and Methods: Seventeen cases were used to tune LET-based optimization, and seven to independently test interfraction plan robustness. For each patient, a reference plan was optimized on biologically-weighted dose cost functions. For the first group, 7 LET-optimized plans were obtained by increasing the gross tumor volume (GTV) minimum LET Results: GTV L Conclusion: LET
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