Evidence map›Paper›PMID 39206217›Full record

ArticleTherapeutic advances in neurological disorders2024

Pattern of pareses in 5q-spinal muscular atrophy.

Zeljko Uzelac, Beate Schwäble, Johannes Dorst, Angela Rosenbohm, Kurt Wollinsky, Claudia D Wurster, Janna S Steinbreier, Albert C Ludolph

Abstract read
In one paragraph

Article in Therapeutic advances in neurological disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeljko UzelacDepartment of Neurology, Ulm University, Ulm, Germany.ORCID https://orcid.org/0000-0003-2479-2025
Beate SchwäbleDepartment of Neurology, Ulm University, Ulm, Germany.
Johannes DorstDepartment of Neurology, Ulm University, Ulm, Germany.ORCID https://orcid.org/0000-0003-0338-5439
Angela RosenbohmDepartment of Neurology, Ulm University, Ulm, Germany.ORCID https://orcid.org/0000-0001-9700-0338
Kurt WollinskyDepartment of Anesthesiology, RKU-University and Rehabilitation Clinics, Ulm University, Ulm, Germany.
Claudia D WursterDepartment of Neurology, Ulm University, Ulm, Germany.
Janna S SteinbreierDepartment of Neurology, Ulm University, Ulm, Germany.
Albert C LudolphDepartment of Neurology, Ulm University, Oberer Eselsberg 45, 89091 Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This prospective study investigates the pattern of pareses in 5q-associated spinal muscular atrophy (SMA) to identify disease-specific characteristics and potential differences from amyotrophic lateral sclerosis (ALS) and spinobulbar muscular atrophy (SBMA). Detailed knowledge about pareses patterns in SMA facilitates differential diagnosis and supports therapeutic monitoring. Methods: Between January 2021, and June 2021, 66 SMA patients (59.1% male, aged 33.6 ± 15.2 years) were included in the study. Most patients had SMA type II ( Results: In both, upper and lower limbs muscle weakness was less pronounced in distal (upper limbs: MRC median 3.0 (interquartile range 1.5-3.5); lower limbs: 1.5 (0.5-3.0)) compared to proximal muscle groups (upper limbs: 2.0 (1.5-2.6); Conclusion: We identified a specific pattern of muscle paresis in SMA which is different from the pattern of paresis in ALS and SBMA. As a rule of thumb, the pattern of pareses is similar, but not identical to ALS in distal, but different in proximal muscle groups.

Indexed as

amyotrophic lateral sclerosismotor neuron diseaseparesis patternspinal muscular atrophy

Identifiers

PMID39206217
PMCPMC11350530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.