Evidence map›Paper›PMID 39206103›Full record

ArticleJournal of clinical medicine research2024

A Complex Interplay of Tumor Microenvironment Could Enhance Cholangiocarcinoma Progression Even After Surgery: A Prospective Study.

Asmaa M Zahran, Amal Rayan, Khaled Saad, Khalid Rezk, Ahmed Soliman, Mohamed Ahmed Rizk, Aya Mohammed Mahros, Essam-Eldeen M O Mahran, Mohamed Ahmed Bashir, Heba M Elmasry and 4 more

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Article in Journal of clinical medicine research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asmaa M ZahranClinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Amal RayanClinical Oncology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Khaled SaadPediatric Department, Faculty of Medicine, Assiut University, 71516 Assiut, Egypt.
Khalid RezkSurgical Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Ahmed SolimanGeneral Surgery Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed Ahmed RizkGeneral Surgery Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Aya Mohammed MahrosDepartment of Hepatology, Gastroenterology, and Infectious Diseases, Kafrelsheikh University, Kafrelsheikh, Egypt.
Essam-Eldeen M O MahranDepartment of Tropical Medicine and Gastroenterology, Faculty of Medicine, New Valley University, New Valley, Egypt.
Mohamed Ahmed BashirClinical Pathology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Heba M ElmasryClinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Zeinab Albadry M ZahranClinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ahmed Khalid IbrahimFaculty of Medicine, National Assiut University, Assiut, Egypt.
Mohsen M FageehDirector of forensic toxicology services, FMSC, Jazan, Saudi Arabia.
Doaa A GamalClinical Oncology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The current study was conducted to explore the impact of macrophages and programmed cell death protein 1 (PD-1) expression on tumor-infiltrating lymphocytes (TILs) on treatment outcomes and to define the interaction between these factors and the clinicopathologic features of advanced cholangiocarcinoma (CCA) patients. Methods: Twenty-five patients with metastatic CCA were recruited for the current study from El-Rajhi Hospital and the Clinical Oncology Department of Assiut University. Additionally, 19 healthy controls were included. Before the flow cytometric detection of immune cells, the diagnosis and staging of CCA were performed based on surgical intervention, imaging, carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) determinations. This was followed by flow cytometric detection of CD4 Results: The current results revealed higher levels of CD4 Conclusions: CCA has a desmoplastic microenvironment with complex immunologic topography and tumor-reactive stroma. The immune landscape of the peripheral blood mononuclear cells (PBMCs) in CCA patients before treatment could reflect the state of systemic immune function and response to treatments. Our results revealed that T-lymphocytes correlated with better prognosis while macrophages and PD-1

Indexed as

CholangiocarcinomaMacrophagesPBMNCsPD-1+ expressionProgression-free survival

Identifiers

PMID39206103
PMCPMC11349130

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