Evidence map›Paper›PMID 39206046›Full record

ArticleJournal of the Endocrine Society2024

Fragility Fractures and Cortisol Secretion in Patients With Nonfunctioning Adrenal Incidentalomas.

Vittoria Favero, Elisa Cairoli, Cristina Eller-Vainicher, Valentina Morelli, Antonio Stefano Salcuni, Silvia Della Casa, Giovanna Muscogiuri, Carla Columbu, Flavia Pugliese, Sabrina Corbetta and 3 more

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Lowering the dexamethasone suppression test cut-off: is it time yet?Journal of endocrinological investigation · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. A longitudinal study of dual-energy X-ray absorptiometry status in menopausal women with adrenal tumors.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vittoria FaveroDepartment of Medical Biotechnology and Translational Medicine, University of Milan, 20100 Milan, Italy.
Elisa CairoliUOSD Bone Metabolic Diseases and Diabetes, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20100 Milan, Italy.
Cristina Eller-VainicherUnit of Endocrinology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico Milan, 20100 Milan, Italy.
Valentina MorelliUOSD Bone Metabolic Diseases and Diabetes, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20100 Milan, Italy.
Antonio Stefano SalcuniUnit of Endocrinology and Metabolism, University Hospital S. Maria Della Misericordia, 33100 Udine, Italy.
Silvia Della CasaDepartment of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli, 00100 Rome, Italy.
Giovanna MuscogiuriDipartimento di Medicina Clinica e Chirurgia, Unità di Endocrinologia, Andrologia e Diabetologia-Università Federico II di Napoli, 80110 Naples, Italy.
Carla ColumbuUnit of Endocrinology "Casa Sollievo della Sofferenza," Hospital, IRCCS, San Giovanni Rotondo, 71013 Foggia, Italy.
Flavia PuglieseUnit of Endocrinology "Casa Sollievo della Sofferenza," Hospital, IRCCS, San Giovanni Rotondo, 71013 Foggia, Italy.
Sabrina CorbettaUOSD Bone Metabolic Diseases and Diabetes, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20100 Milan, Italy.
Luca PersaniDepartment of Medical Biotechnology and Translational Medicine, University of Milan, 20100 Milan, Italy.ORCID https://orcid.org/0000-0003-2068-9581
Alfredo ScillitaniUnit of Endocrinology "Casa Sollievo della Sofferenza," Hospital, IRCCS, San Giovanni Rotondo, 71013 Foggia, Italy.
Iacopo ChiodiniDepartment of Medical Biotechnology and Translational Medicine, University of Milan, 20100 Milan, Italy.ORCID https://orcid.org/0000-0001-7594-3300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: The risk of vertebral fractures (VFx) in patients with nonfunctioning adrenal incidentalomas (NFAI) is unknown. Objective: This work aimed to assess in NFAI patients the prevalence and incidence of VFx and a hormonal marker to identify patients at risk. Methods: A retrospective, cross-sectional, and longitudinal study of outpatients was conducted. A total of 306 NFAI patients (cross-sectional arm) and 213 controls were evaluated for VFx prevalence; 85 NFAI patients (longitudinal arm, follow-up 30.3 ± 17.5 months) were evaluated for VFx incidence. Main outcome measures included serum cortisol after 1 mg-dexamethasone test (F-1mgDST), lumbar spinal (LS), and femoral neck (FN) bone mineral density (BMD) and VFx presence, by radiograph of the spine. Results: Cross-sectional arm: prevalent VFx associated with F-1mgDST with a cutoff of 1.2 µg/dL (33 nmol/L, area under the curve 0.620 ± 0.39; Conclusion: In NFAI patients, F-1mgDST levels greater than or equal to 1.2 µg/L (33 nmol/L) are associated with prevalent VFx and may identify patients at risk of incident VFx.

Indexed as

adrenal incidentalomabone densitycortisolfracturesosteoporosis

Identifiers

PMID39206046
PMCPMC11348107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.