Evidence map›Paper›PMID 39205500›Full record

ArticleDevelopmental psychobiology2024

Agomelatine Is Unable to Attenuate Kainic Acid-Induced Deficits in Early Life Communicative Behavior.

Matthew S Binder, Zachary J Pranske, Samantha L Hodges, Paige D Womble, Eliesse M Kwok, Saul I Quintero, Andrew D Kim, David A Narvaiz, Joaquin N Lugo

Abstract read
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In one paragraph

Article in Developmental psychobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew S BinderDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Zachary J PranskeDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Samantha L HodgesInstitute of Biomedical Studies, Baylor University, Waco, Texas, USA.
Paige D WombleDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Eliesse M KwokDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Saul I QuinteroDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Andrew D KimDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
David A NarvaizDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Joaquin N LugoDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.ORCID 0000-0001-6874-8718

Funding

Signaling Mechanisms Underlying Epilepsy and Autism CormorbidityR15NS088776 · NINDS · BAYLOR UNIVERSITY · PI JOAQUIN N LUGO · 2015 to 2026
$1.8M
NINDS NIH HHS R15 NS088776NINDS NIH HHS R15S088776
6 · The paper itself

Abstract

Early life seizures are associated with a variety of behavioral comorbidities. Among the most prevalent of these are deficits in communication. Auditory communicative behaviors in mice, known as ultrasonic vocalizations (USVs), can be used to assess potential treatments. Agomelatine is a melatonin agonist that effectively reduces behavioral comorbidities of seizures in adults; however, its ability to attenuate seizure-induced communicative deficits in neonates is unknown. To address this, we administered C57 mice either saline or kainic acid (KA) on postnatal day (PD) 10. The mice then received either agomelatine or saline 1-h post-status epilepticus. On PD 11, we assessed the quantity of USVs produced, the duration, peak frequency, fundamental frequency, and amplitude of the vocalizations, as well as the call type utilization. We found that KA increased vocal production and reduced USV variability relative to controls. KA also increased USV duration and amplitude and significantly altered the types of calls produced. Agomelatine did not attenuate any of the deficits. Our study is the first to assess agomelatine's efficacy to correct USVs and thus provides an important point of context to the literature, indicating that despite its high therapeutic efficacy to attenuate other behavioral comorbidities of seizures, agomelatine's ability to correct neonatal communicative deficits is limited.

Indexed as

AcetamidesKainic AcidMice, Inbred C57BLVocalization, AnimalAnimalsAnimals, NewbornDisease Models, AnimalFemaleMaleMiceNaphthalenesSeizuresStatus EpilepticusAcetamidesagomelatineKainic AcidNaphthalenescommunicationcomorbiditymelatoninseizurevocalizations

Identifiers

PMID39205500
PMCPMC11376987

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.