Evidence map›Paper›PMID 39205349›Full record

ArticleInternational journal of hygiene and environmental health2024

Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.

Marissa Hauptman, Medina S Jackson-Browne, Stefanie Busgang, Syam S Andra, Marisa A Patti, Noelle B Henderson, Paul Curtin, Susan L Teitelbaum, Keith Acosta, Michelle Maciag and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marissa HauptmanDivision of General Pediatrics, Boston Children's Hospital, Boston, MA, USA; Region 1 New England Pediatric Environmental Health Specialty Unit, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: Marissa.Hauptman@childrens.harvard.edu.
Medina S Jackson-BrowneDivision of General Pediatrics, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Stefanie BusgangDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Health Exposure Analysis Resource Data Center, New York, NY, USA.
Syam S AndraDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Lautenberg Laboratory, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marisa A PattiA.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Noelle B HendersonDepartment of Environmental Health, Boston University School of Public Health, Boston, MA, USA.
Paul CurtinDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Health Exposure Analysis Resource Data Center, New York, NY, USA.
Susan L TeitelbaumDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Health Exposure Analysis Resource Data Center, New York, NY, USA.
Keith AcostaDivision of General Pediatrics, Boston Children's Hospital, Boston, MA, USA; Region 1 New England Pediatric Environmental Health Specialty Unit, Boston, MA, USA.
Michelle MaciagDivision of Allergy and Immunology, Boston Children's Hospital, Boston, MA, USA.
Jonathan M GaffinHarvard Medical School, Boston, MA, USA; Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.
Carter R PettyInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Robert O WrightDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Health Exposure Analysis Resource Data Center, New York, NY, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Diane R GoldHarvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Respiratory Epidemiology, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Wanda PhipatanakulHarvard Medical School, Boston, MA, USA; Division of Allergy and Immunology, Boston Children's Hospital, Boston, MA, USA; Institutional Centers for Clinical and Translational Research, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Gary Adamkiewicz · 1985 to 2026
$44.6M
Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2015 to 2025
$26.4M
Untargeted Analysis ResourceU2CES026561 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROBERT O · 2015 to 2025
$24.5M
SICAS- Diversity SupplementU01AI110397 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2015 to 2020
$8.8M
Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary DysplasiaR01ES030100 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2019 to 2023
$3.7M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Air Pollution, Stress and Asthma Morbidity Risk: Role of Biological and Geospatial MarkersK23ES031663 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI HAUPTMAN, MARISSA · 2021 to 2025
$984k
Associations between Perfluoroalkyl Substances (PFAS) Exposure and Aeroallergen Sensitization among Infants at High-Risk for Developing AsthmaK01HL171354 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Medina Samira Jackson-Browne · 2024 to 2026
$484k
ATSDR CDC HHS R01 TS000296NHLBI NIH HHS K01 HL171354NIAID NIH HHS K24 AI106822NIAID NIH HHS U01 AI110397NIEHS NIH HHS K23 ES031663NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES030100NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026561
6 · The paper itself

Abstract

backgroundThe burden of pediatric asthma and other allergic diseases is not evenly distributed among United States populations.

objectiveTo determine whether urinary biomarkers are associated with asthma morbidity, and if associations vary by child race, ethnicity and sex.

methodsThis study includes n = 152 children with physician-diagnosed asthma who participated in the School Inner-City Asthma Intervention Study (SICAS-2). Metabolites of phenol, paraben, polycyclic aromatic hydrocarbons, and phthalate analytes were analyzed from urine samples collected at baseline. Asthma symptom days over the past 2 weeks were dichotomized to no asthma symptom days or any asthma symptom days. Cross-sectional regression models were adjusted for age, sex, number of colds, household income, prescription control, race and ethnicity, body mass index (BMI) percentile, and smoke exposure. Weighted quantile sum regression was used to analyze each chemical class and a total mixture effect, controlling for the same covariates. Analyses were conducted with the assistance of the National Institute of Environmental Health Sciences Children's Health Exposure Analysis Resource (CHEAR).

resultsParticipants were mostly Hispanic/Latino and low income with an average age of 7.83 years and the average maximum asthma symptom days over the past two weeks of 2.13 (standard deviation: 3.56). The maximum concentrations indicate extreme values for several chemicals, including bisphenol-3, 2,5-dichlorophenol, propyl and methyl parabens, triclosan, methyl paraben and cotinine. We found a significant interaction effect and differing contributions of analytes for children with allergen sensitivity versus those that did not. For stratified analyses assessing effect modification by child race and ethnicity, weighted quantile sum interaction models showed reduced odds of asthma symptoms to a greater magnitude in children of other races and ethnicities compared to Black, Non-Hispanic children.

conclusionsPreliminary analyses of the association between environmental chemical exposure and asthma symptoms among inner-city children revealed an inverse association, which may be due to personal care and medication use and can be understood further in future analyses. Beneficial effects were detected for most of the chemicals.

Indexed as

AsthmaBiomarkersEnvironmental ExposurePolycyclic Aromatic HydrocarbonsAdolescentChildCross-Sectional StudiesEnvironmental PollutantsFemaleHumansMaleParabensPhenolsPhthalic AcidsSchoolsUrban PopulationBiomarkersEnvironmental PollutantsParabensPhenolsphthalic acidPhthalic AcidsPolycyclic Aromatic HydrocarbonsChemical mixturesChildhood asthmaSchoolUrinary biomarkers

Identifiers

PMID39205349
PMCPMC11972426

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.