Evidence map›Paper›PMID 39205309›Full record

ArticleViruses2024

HIV-MTB Co-Infection Reduces CD4+ T Cells and Affects Granuloma Integrity.

Suyue Huang, Maoying Liu, Hui Zhang, Wei Song, Wenjuan Guo, Yanling Feng, Xin Ma, Xia Shi, Jianjian Liu, Li Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Viruses · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Suyue HuangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Maoying LiuDepartment of Microbiology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China.
Hui ZhangDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Wei SongShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Wenjuan GuoShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Yanling FengShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Xin MaShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Xia ShiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Jianjian LiuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Li LiuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Tangkai QiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Zhenyan WangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Bo YanShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.ORCID 0000-0002-7308-8942
Yinzhong ShenShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.ORCID 0000-0002-7604-5139

Funding

Science and Technology Commission of Shanghai Municipality 18411970800Science and Technology Commission of Shanghai Municipality 20MC1920100Science and Technology Commission of Shanghai Municipality 21Y31900400Science and Technology Commission of Shanghai Municipality ZD2021CY001Shanghai Hospital Development Center SHDC2020CR6025Shanghai Hospital Development Center SHDC22021317
6 · The paper itself

Abstract

Granuloma is a crucial pathological feature of tuberculosis (TB). The relationship between CD4+ T cells in both peripheral blood and granulomatous tissue, and the integrity of granulomas in Human Immunodeficiency Virus (HIV)-MTB co-infection, remains unexplored. This study collected biopsy specimens from 102 TB patients (53 with HIV-MTB co-infection and 49 only with TB). Hematoxylin and eosin (HE) staining and immunohistochemical staining were performed, followed by microscopic examination of the integrity of tuberculous granulomas. Through statistical analysis of peripheral blood CD4+ T cell counts, tissue CD4+ T cell proportion, and the integrity of granulomas, it was observed that HIV infection leads to poor formation of tuberculous granulomas. Peripheral blood CD4+ T cell counts were positively correlated with granuloma integrity, and there was a similar positive correlation between tissue CD4+ T cell proportions and granuloma integrity. Additionally, a positive correlation was found between peripheral blood CD4+ T cell counts and the proportion of CD4+ T cells in granuloma tissues. Therefore, HIV infection could impact the morphology and structure of tuberculous granulomas, with a reduced proportion of both peripheral blood and tissue CD4+ T lymphocytes.

Indexed as

CD4-Positive T-LymphocytesCoinfectionGranulomaHIV InfectionsTuberculosisAdultCD4 Lymphocyte CountFemaleHumansMaleMiddle AgedMycobacterium tuberculosisCD4+ T cellco-infectiongranulomaHIVtuberculosis

Identifiers

PMID39205309
PMCPMC11360352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.