Evidence map›Paper›PMID 39204444›Full record

ArticlePharmaceutics2024

The Development of a Chocolate-Based Chewable Tablet of Prednisolone-Enhancing the Palatability of Steroids for Pediatric Use.

Okhee Yoo, Edith Tang, Md Lokman Hossain, Britta S von Ungern-Sternberg, David Sommerfield, Chloe Heath, Neil Hauser, R Nazim Khan, Cornelia Locher, Minh Nguyen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Okhee YooDiscipline of Pharmacy, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-7285-1953
Edith TangDiscipline of Pharmacy, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-6266-6874
Md Lokman HossainDiscipline of Pharmacy, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-6339-2767
Britta S von Ungern-SternbergInstitute for Pediatric Perioperative Excellence, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-8043-8541
David SommerfieldInstitute for Pediatric Perioperative Excellence, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-3600-1315
Chloe HeathInstitute for Pediatric Perioperative Excellence, The University of Western Australia, Perth, WA 6009, Australia.
Neil HauserInstitute for Pediatric Perioperative Excellence, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-8868-0690
R Nazim KhanInstitute for Pediatric Perioperative Excellence, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-3349-5006
Cornelia LocherDiscipline of Pharmacy, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-8773-3036
Minh NguyenDiscipline of Pharmacy, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.
Lee Yong LimDiscipline of Pharmacy, School of Allied Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-7307-0742

Funding

Australian and New Zealand College of Anaesthetists EI23/005
6 · The paper itself

Abstract

Oral liquid prednisolone medications have poor acceptance among paediatric patients due to ineffective masking of the bitterness taste of prednisolone. This study aimed to develop a child-friendly prednisolone tablet using a patented chewable chocolate-based delivery system (CDS) previously applied successfully to mask the bitterness tastes of midazolam and tramadol. Prednisolone sodium phosphate (PSP) and prednisolone base (PB) CDS tablets were prepared, and the manufacturing process was optimised using a design of experiments (DoE) approach. Stability was assessed by quantifying residual drug content via a validated HPLC assay. A pilot randomised crossover taste study involving 25 young adult volunteers evaluated taste-masking effectiveness against Redipred™, a commercial oral PSP liquid medicine. The results showed that the PSP CDS tablet was chemically stable following storage for three months at ambient temperature, while the PB CDS tablet was unstable. The optimised PSP CDS tablet, manufactured at 50 °C with a stirring time of 26 h, was found to release over 80% of its drug load within 20 min in 0.1 M HCl and had a significantly better mean taste score compared to Redipred™ (7.08 ± 2.40 vs. 5.60 ± 2.33,

Indexed as

chocolate-based delivery systemmedication adherencepaediatric formulationprednisolonetaste masking

Identifiers

PMID39204444
PMCPMC11359696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.