Design and Fabrication of Sustained Bacterial Release Scaffolds to Support the Microbiome.

Anne Marie Klein, Nanang Qosim, Gareth Williams, Mohan Edirisinghe, Rupy Kaur Matharu

Abstract read

In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne Marie KleinDepartment of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

Nanang QosimDepartment of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.ORCID 0000-0002-1910-9423

Gareth WilliamsUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0002-3066-2860

Mohan EdirisingheDepartment of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

Rupy Kaur MatharuDepartment of Civil, Environmental & Geomatic Engineering, University College London, Chadwick Building, Gower Street, London WC1E 6BT, UK.ORCID 0000-0003-3687-5119

Funding

Engineering and Physical Sciences Research Council EP/L023059/1Engineering and Physical Sciences Research Council EP/N034228/1Engineering and Physical Sciences Research Council EP/S016872/1

6 · The paper itself

Abstract

Fibres in the micro- and nanometre scale are suited to a broad range of applications, including drug delivery and tissue engineering. Electrospinning is the manufacturing method of choice, but it has some limitations. Novel pressure-driven fibre-forming techniques, like pressurised gyration (PG), overcome these limitations; however, the compatibility of PG with biological materials has not yet been evaluated in detail. For the first time, this limitation of PG was investigated by optimising PG for microbial cell processing and incorporating bacterial cultures into fibrous polymeric scaffolds for sustained release. Multiple polymer-solvent systems were trialled, including polyvinylpyrrolidone (PVP)/phosphate-buffered saline (PBS) 25%

Indexed as

bioactive fibresdrug deliverymicrofibresprobioticssustained release

Identifiers

PMID39204410

DOI10.3390/pharmaceutics16081066

PMCPMC11358975

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.