Evidence map›Paper›PMID 39204408›Full record

ArticlePharmaceutics2024

Osteoblastic Cell Sheet Engineering Using P(VCL-HEMA)-Based Thermosensitive Hydrogels Doped with pVCL@Icariin Nanoparticles Obtained with Supercritical CO

Rubén García-Sobrino, Isabel Casado-Losada, Carmen Caltagirone, Ana García-Crespo, Carolina García, Juan Rodríguez-Hernández, Helmut Reinecke, Alberto Gallardo, Carlos Elvira, Enrique Martínez-Campos

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rubén García-SobrinoPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.ORCID 0000-0002-9900-4241
Isabel Casado-LosadaPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.ORCID 0000-0002-5436-6433
Carmen CaltagironePolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.
Ana García-CrespoPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.
Carolina GarcíaPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.ORCID 0000-0003-1907-0415
Juan Rodríguez-HernándezPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.
Helmut ReineckePolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.
Alberto GallardoPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.
Carlos ElviraPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.ORCID 0000-0001-6007-5774
Enrique Martínez-CamposPolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC) Calle Juan de la Cierva, n° 3, 28006 Madrid, Spain.

Funding

Agencia Estatal de Investigación PDC2022-133446-I00Instituto de Salud Carlos III PI21/00858Ministerio de Ciencia, Innovación y Universidades RTI2018-096328-B-I00
6 · The paper itself

Abstract

New clinical strategies for treating severe bone and cartilage injuries are required, especially for use in combination with implant procedures. For this purpose, p(VCL-co-HEMA) thermosensitive hydrogels have been activated with icariin-loaded nanoparticles to be used as bone-cell-harvesting platforms. Supercritical CO

Indexed as

bone differentiationcell sheet engineeringdrug deliveryicariinsupercritical CO2 technologythermosensitive hydrogel

Identifiers

PMID39204408
PMCPMC11359487

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.