Evidence map›Paper›PMID 39204351›Full record

ArticlePharmaceutics2024

Co-Administration of Amiodarone Increases Bleeding by Affecting Rivaroxaban Pharmacokinetics in Patients with Atrial Fibrillation.

Huamin Ding, Zi Wang, Jia Wang, Yao Yao, Chi Zhang, Houwen Lin, Yong Zhou, Zhichun Gu, Qianzhou Lv, Xiaoye Li

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huamin DingDepartment of Pharmacy, Punan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.
Zi WangDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Jia WangDepartment of Pharmacy, Punan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.ORCID 0000-0002-8165-1184
Yao YaoDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Chi ZhangDepartment of Pharmacy, Punan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.ORCID 0000-0002-1443-3734
Houwen LinDepartment of Pharmacy, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Yong ZhouDepartment of Pharmacy, Punan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.
Zhichun GuDepartment of Pharmacy, Punan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.ORCID 0000-0002-1245-9690
Qianzhou LvDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0002-6353-7767
Xiaoye LiDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Funding

Academic leader training program of Pudong New Area HealthCommission (PWRd2023-02)Research project on high quality development of Hospital pharmacy, National Institute of Hospital Administration, NHC, China (NIHAYS2305)Science and Technology Development Foundation of Shanghai Pudong New Area (PKJ2023-Y17)Talent Project established by Chinese Pharmaceutical Association Hospital Pharmacy Department (CPA-Z05-ZC-2023-003)
6 · The paper itself

Abstract

This study aimed to investigate the impact of the drug-drug interaction between rivaroxaban and amiodarone on the clinical outcomes in patients with non-valvular atrial fibrillation (NVAF), focusing on pharmacokinetic and pharmacodynamic (PK/PD) aspects. A prospective study enrolling 174 patients with NVAF who were treated with rivaroxaban was conducted. The patients were divided into two groups based on postoperative antiarrhythmic and anticoagulation strategies: the rivaroxaban group (Control group) and the rivaroxaban plus amiodarone group (Riv/Amio group). The trough plasma concentrations (C

Indexed as

amiodaronebleeding eventsDDIPK/PDrivaroxaban

Identifiers

PMID39204351
PMCPMC11359575

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.