Evidence map›Paper›PMID 39204334›Full record

ArticlePharmaceutics2024

Clinically Relevant Characterization and Comparison of Ryaltris and Other Anti-Allergic Nasal Sprays.

Virginia Patterlini, Fabiola Guareschi, Davide D'Angelo, Simone Baldini, Suada Meto, Dalia Mostafa Kamal, Paolo Fabrizzi, Francesca Buttini, Ralph Mösges, Fabio Sonvico

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Orange PeelPharmaceutics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Virginia PatterliniDipartimento di Scienze Degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0009-0003-0522-8303
Fabiola GuareschiDipartimento di Scienze Degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Davide D'AngeloDipartimento di Scienze Degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0000-0002-7843-1201
Simone BaldiniMenarini Group, Via Sette Santi 1-3, 50131 Florence, Italy.
Suada MetoMenarini Group, Via Sette Santi 1-3, 50131 Florence, Italy.
Dalia Mostafa KamalMenarini Group, Via Sette Santi 1-3, 50131 Florence, Italy.
Paolo FabrizziMenarini Group, Via Sette Santi 1-3, 50131 Florence, Italy.
Francesca ButtiniDipartimento di Scienze Degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0000-0002-4472-4823
Ralph MösgesInstitute of Medical Statistics and Computational Biology (IMSB), Medical Faculty, University at Cologne, 50923 Cologne, Germany.ORCID 0000-0002-1928-810X
Fabio SonvicoDipartimento di Scienze Degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0000-0001-7372-1456

Funding

Menarini Group Private financial support
6 · The paper itself

Abstract

The deposition, residence time, and dissolution profile of nasal suspensions containing corticosteroids play a key role in their in vivo efficacy after administration. However, the conventional methods available to characterize nasal products appear to be unsuitable to exhaustively cover these aspects. The work aims to investigate technological aspects of Ryaltris (mometasone furoate and olopatadine hydrochloride nasal spray) compared to other commercial anti-allergic nasal products, namely, Dymista (azelastine hydrochloride and fluticasone propionate), Nasonex (mometasone furoate), and Avamys (fluticasone furoate). Innovative characterization methods were combined with more traditional approaches to investigate the anti-allergic nasal sprays. These methods applied together allowed to differentiate between the different products and provided a clear picture of the nasal product behavior in terms of drug dissolution and deposition. In particular, the dissolution tests were performed exploiting the Respicell

Indexed as

corticosteroidsdissolution test for inhalation productsnasal cast depositionnasal drug delivery

Identifiers

PMID39204334
PMCPMC11357686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.