Evidence map›Paper›PMID 39204316›Full record

ArticlePharmaceutics2024

Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs.

Carla Sardo, Giulia Auriemma, Carmela Mazzacano, Claudia Conte, Virgilio Piccolo, Tania Ciaglia, Marta Denel-Bobrowska, Agnieszka B Olejniczak, Donatella Fiore, Maria Chiara Proto and 2 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carla SardoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0002-7819-9449
Giulia AuriemmaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0001-9547-0969
Carmela MazzacanoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.
Claudia ConteDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.
Virgilio PiccoloDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.
Tania CiagliaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0002-6592-4373
Marta Denel-BobrowskaInstitute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.ORCID 0000-0003-4379-0367
Agnieszka B OlejniczakInstitute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.ORCID 0000-0003-4628-9017
Donatella FioreDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0002-0703-7231
Maria Chiara ProtoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0002-7066-174X
Patrizia GazzerroDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0003-0576-2955
Rita Patrizia AquinoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.

Funding

EU-NextGenerationEU grant CN00000041 "National Center for Gene Therapy and Drugs based on RNA Technology" (concession number 1035 of 17 June 2022-PNRR MUR-M4C2-Investment 1.4 Call "National Centers", financed by the EU-NextGenerationEU), code project (CUP) D43C22001200001European Union CUP D53D23010090001- Grant Assignment Decree No. 1064 of 18/07/2023 adopted by the Italian Ministry of Ministry of University and Research (MUR)Polish Ministry of Science and Higher Education project POL-OPENSCREEN (decision no. DIR/WK/2018/06 of 24.10.2018)
6 · The paper itself

Abstract

In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic "inulinated" analog of the "pegylated" PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, and SEM analyses, was conducted to elucidate the core/shell architecture of the carriers and in vitro cyto- and hemo-compatibility were assayed. The entrapment and in vitro delivery of sorafenib tosylate (

Indexed as

crew-cut nanoparticlesFALTinulinPEG alternativePLAsorafenib tosylate

Identifiers

PMID39204316
PMCPMC11359108

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.