Evidence map›Paper›PMID 39204315›Full record

ArticlePharmaceutics2024

Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?

Glauco Henrique Balthazar Nardotto, Elin M Svenson, Valdes Roberto Bollela, Adriana Rocha, Svetoslav Nanev Slavov, João Paulo Bianchi Ximenez, Oscar Della Pasqua, Vera Lucia Lanchote

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Glauco Henrique Balthazar NardottoFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, Brazil.ORCID 0000-0001-7024-4252
Elin M SvensonDepartment of Pharmacy, Uppsala University, 75123 Uppsala, Sweden.ORCID 0000-0002-0093-6445
Valdes Roberto BollelaFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14049-900, Brazil.ORCID 0000-0002-8221-4701
Adriana RochaFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, Brazil.ORCID 0000-0003-4824-6571
Svetoslav Nanev SlavovCenter for Viral Surveillance and Serological Evaluation-CeVIVAs, Butantan Institute, Sao Paulo 05503-900, Brazil.ORCID 0000-0003-0805-6140
João Paulo Bianchi XimenezFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, Brazil.ORCID 0000-0002-6414-5220
Oscar Della PasquaClinical Pharmacology & Therapeutics Group, University College London, London WC1J 9JP, UK.ORCID 0000-0002-6211-1430
Vera Lucia LanchoteFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, Brazil.ORCID 0000-0002-0074-4953

Funding

Brazilian National Council for Scientific and Technological Development (CNPq) 303142/2019-7The São Paulo Research Foundation (FAPESP) 2016/05624-0 and 2018/05616-3
6 · The paper itself

Abstract

The present study aims to characterise the pharmacokinetics of rifampicin (RIF) in tuberculosis (TB) patients with and without HIV co-infection, considering the formation of 25-O-desacetyl-rifampicin (desRIF). It is hypothesised that the metabolite formation, HIV co-infection and drug formulation may further explain the interindividual variation in the exposure to RIF. Pharmacokinetic, clinical, and demographic data from TB patients with (TB-HIV+ group;

Indexed as

25-O-desacetyl-rifampicinbioavailabilityhuman immunodeficiency viruspopulation pharmacokineticspulmonary tuberculosisrifampicin

Identifiers

PMID39204315
PMCPMC11359463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.