Evidence map›Paper›PMID 39204139›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Synthesis and Biochemical Evaluation of Ethanoanthracenes and Related Compounds: Antiproliferative and Pro-Apoptotic Effects in Chronic Lymphocytic Leukemia (CLL).

James P McKeown, Andrew J Byrne, Sandra A Bright, Clara E Charleton, Shubhangi Kandwal, Ivan Čmelo, Brendan Twamley, Anthony M McElligott, Darren Fayne, Niamh M O'Boyle and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James P McKeownSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College, The University of Dublin, East End 4/5, Dublin 2, D02 PN40 Dublin, Ireland.
Andrew J ByrneSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College, The University of Dublin, East End 4/5, Dublin 2, D02 PN40 Dublin, Ireland.
Sandra A BrightSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, D02 R590 Dublin, Ireland.
Clara E CharletonSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College, The University of Dublin, East End 4/5, Dublin 2, D02 PN40 Dublin, Ireland.
Shubhangi KandwalMolecular Design Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, D02 R590 Dublin, Ireland.
Ivan ČmeloMolecular Design Group, School of Chemical Sciences, Dublin City University, Glasnevin, D09 V209 Dublin, Ireland.ORCID 0000-0001-7787-8653
Brendan TwamleySchool of Chemistry, Trinity College Dublin, Dublin 2, D02 P3X2 Dublin, Ireland.
Anthony M McElligottDiscipline of Haematology, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital and Trinity College, Dublin 8, D08 W9RT Dublin, Ireland.ORCID 0000-0003-3276-1341
Darren FayneMolecular Design Group, School of Chemical Sciences, Dublin City University, Glasnevin, D09 V209 Dublin, Ireland.
Niamh M O'BoyleSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College, The University of Dublin, East End 4/5, Dublin 2, D02 PN40 Dublin, Ireland.ORCID 0000-0001-5660-4944
D Clive WilliamsSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, D02 R590 Dublin, Ireland.
Mary J MeeganSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College, The University of Dublin, East End 4/5, Dublin 2, D02 PN40 Dublin, Ireland.ORCID 0000-0002-8930-5753

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation and accumulation of neoplastic B lymphocytes in the blood, lymph nodes, bone marrow and spleen. We report the synthesis and antiproliferative effects of a series of novel ethanoanthracene compounds in CLL cell lines. Structural modifications were achieved via the Diels-Alder reaction of 9-(2-nitrovinyl)anthracene and 3-(anthracen-9-yl)-1-arylprop-2-en-1-ones (anthracene chalcones) with dienophiles, including maleic anhydride and

Indexed as

antiproliferativeB cellchalconechronic lymphocytic leukemia (CLL)ethanoanthracenepro-apoptotic

Identifiers

PMID39204139
PMCPMC11359702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.