Evidence map›Paper›PMID 39203906›Full record

ArticleNutrients2024

Promising Effects of Novel Supplement Formulas in Preventing Skin Aging in 3D Human Keratinocytes.

Angela Punzo, Matteo Perillo, Alessia Silla, Marco Malaguti, Silvana Hrelia, Diogo Barardo, Cristiana Caliceti, Antonello Lorenzini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angela PunzoDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-3026-6830
Matteo PerilloDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-8778-6258
Alessia SillaDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy.
Marco MalagutiDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0003-0349-7772
Silvana HreliaDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0001-7857-4512
Diogo BarardoNOVOS Labs, New York, NY 10017, USA.ORCID 0000-0001-6177-0728
Cristiana CalicetiDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-6740-5331
Antonello LorenziniDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-9615-9697

Funding

MUR PRIN2022 Prot. 2022LW54KC
6 · The paper itself

Abstract

Dietary intervention is considered a safe preventive strategy to slow down aging. This study aimed to evaluate the protective effects of a commercially available supplement and six simpler formulations against DNA damage in 3D human keratinocytes. The ingredients used are well known and were combined into various formulations to test their potential anti-aging properties. Firstly, we determined the formulations' safe concentration by evaluating cytotoxicity and cell viability through spectrophotometric assays. We then examined the presence of tumor p53 binding protein 1 and phosphorylated histone H2AX foci, which are markers of genotoxicity. The foci count revealed that a 24-h treatment with the supplement did not induce DNA damage, and significantly reduced DNA damage in cells exposed to neocarzinostatin for 2 h. Three of the simpler formulations showed similar results. Moreover, the antioxidant activity was tested using a recently developed whole cell-based chemiluminescent bioassay; results showed that a 24-h treatment with the supplement and three simpler formulations significantly reduced intracellular H

Indexed as

AntioxidantsDietary SupplementsDNA DamageKeratinocytesOxidative StressSkin AgingCell SurvivalHistonesHumansHydrogen PeroxideTumor Suppressor p53-Binding Protein 1AntioxidantsH2AX protein, humanHistonesHydrogen PeroxideTP53BP1 protein, humanTumor Suppressor p53-Binding Protein 153BP1agingantioxidant activityDNA damage focifood supplementshuman 3D keratinocytesγ-H2AX

Identifiers

PMID39203906
PMCPMC11356847

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.