Evidence map›Paper›PMID 39203815›Full record

ArticleNutrients2024

Skeletal Muscle, Skin, and Bone as Three Major Nitrate Reservoirs in Mammals: Chemiluminescence and

Barbora Piknova, Ji Won Park, Khalid J Tunau-Spencer, Audrey Jenkins, David G Hellinga, Peter J Walter, Hongyi Cai, Alan N Schechter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbora PiknovaNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Ji Won ParkNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Khalid J Tunau-SpencerNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0001-5942-4164
Audrey JenkinsMedStar Health Research Institute, Washington, DC 20010, USA.
David G HellingaMedStar Health Research Institute, Washington, DC 20010, USA.
Peter J WalterClinical Mass Spectrometry Core, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0001-8571-398X
Hongyi CaiClinical Mass Spectrometry Core, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Alan N SchechterNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Funding

Clinical Applications of NitriteZ01DK025104 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SCHECHTER, ALAN · 2007 to 2008
$738k
Intramural NIH HHS Z01 DK025104
6 · The paper itself

Abstract

In mammals, nitric oxide (NO) is generated either by the nitric oxide synthase (NOS) enzymes from arginine or by the reduction of nitrate to nitrite by tissue xanthine oxidoreductase (XOR) and the microbiome and further reducing nitrite to NO by XOR or several heme proteins. Previously, we reported that skeletal muscle acts as a large nitrate reservoir in mammals, and this nitrate reservoir is systemically, as well as locally, used to generate nitrite and NO. Here, we report identifying two additional nitrate storage organs-bone and skin. We used bolus of ingested

Indexed as

Bone and BonesMuscle, SkeletalNitratesNitritesNitrogen IsotopesSkinAnimalsLiverLuminescenceMaleNitric OxideSwineNitratesNitric OxideNitritesNitrogen-15Nitrogen Isotopesnitrate in skin and bonenitric oxide reductive pathwayskeletal muscle nitrate reservoir

Identifiers

PMID39203815
PMCPMC11357542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.