Evidence map›Paper›PMID 39203795›Full record

ArticleNutrients2024

Associations of Perchlorate, Nitrate, and Thiocyanate with Bone Mineral Density in the US General Population: A Multi-Cycle Study of NHANES 2011-2018.

Donglan Wang, Ying Zhang, Yayu He, Fengmei Song, Yan Tang, Limou Chen, Yangcan Wang, Fei Yang, Xueqiong Yao

Abstract read
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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Donglan WangSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Ying ZhangSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Yayu HeSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Fengmei SongSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Yan TangSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Limou ChenSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Yangcan WangSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.
Fei YangSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.ORCID 0000-0001-5687-0556
Xueqiong YaoSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421009, China.ORCID 0009-0009-5255-7269

Funding

Natural Science Foundation of Hunan Province 2023JJ40569the Research Foundation of Education Bureau of Hunan Province, China 22A0300
6 · The paper itself

Abstract

backgroundPerchlorate, nitrate, and thiocyanate are widely recognized as endocrine disrupting chemicals, which are closely related to thyroid function. Animal and human studies show a correlation between thyroid hormone and bone mineral density (BMD). However, it remains unknown whether perchlorate, nitrate, and thiocyanate were associated with BMD. This study aimed to explore the association between perchlorate, nitrate, and thiocyanate exposure with BMD.

methodA cross-sectional analysis among 5607 participants from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) was conducted in the present study. Perchlorate, nitrate, and thiocyanate were detected in urine by ion chromatography. Survey-weighted generalized linear regression, restricted cubic splines, and qgcomp models were used to assess the association of BMDs with single and mixed perchlorate, nitrate, and thiocyanate exposures. In addition, age, gender, and BMI stratified these associations.

resultsNegative associations were found between perchlorate and nitrate with BMDs. Furthermore, based on the qgcomp model results, the combined association of perchlorate, nitrate, and thiocyanate exposure was negatively associated with BMDs (β = -0.017, 95% CI: -0.041, -0.024 for total BMD; β = -0.017, 95% CI: -0.029, -0.005 for lumbar BMD). Additionally, there was a significant effect after gender, age, and BMI stratification between perchlorate, nitrate, and thiocyanate with BMDs in the normal weight group (β = -0.015, 95% CI: -0.020, -0.011 for total BMD; β = -0.022, 95% CI: -0.028, -0.016 for lumbar BMD) and children and adolescents group (β = -0.025, 95% CI: -0.031, -0.019 for total BMD; β -0.017, 95% CI: -0.029, -0.005 for lumbar BMD).

conclusionsThe present study indicated a negative correlation between BMDs and urinary perchlorate, nitrate, and thiocyanate levels, with nitrate being the main contributor to the mixture effect. People with normal weight and children and adolescents were more likely to be affected.

Indexed as

Bone DensityNitratesNutrition SurveysPerchloratesThiocyanatesAdolescentAdultAgedChildCross-Sectional StudiesEnvironmental ExposureFemaleHumansMaleMiddle AgedUnited StatesNitratesperchloratePerchloratesthiocyanateThiocyanatesbone mineral densitynational health and nutrition examination surveynitrateperchloratethiocyanate

Identifiers

PMID39203795
PMCPMC11487404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.