ArticleMicromachines2024
Optimizing Printhead Design for Enhanced Temperature Control in Extrusion-Based Bioprinting.
Article in Micromachines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Volumetric Thermal Characterisation of a Controlled Bioprinting Chamber Using Multi-Point Temperature Sensing.Biomimetics (Basel, Switzerland) · 2026Article
- The Promise and Challenges of Bioprinting in Tissue Engineering.Micromachines · 2024Article
- Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This study addresses critical challenges in the field of tissue engineering, specifically in the optimization of bioprinting technologies for the construction of complex, multicellular tissues. By utilizing a homemade piston-driven extrusion-based bioprinting (EBB) printhead, we performed detailed thermal and flow analyses to investigate the effects of temperature variations on the extrusion process of temperature-sensitive gelatin-alginate bioink. Through finite element method (FEM) simulations, we explored the temperature distribution within the printhead and its impact on bioink properties, such as viscosity, pressure, and shear stress. Key findings reveal significant temperature gradients from the printhead barrel to the nozzle tip, influencing bioink extrusion and filament morphology. This study further introduces an innovative hardware optimization with thermal insulators, designed to mitigate heat loss at the nozzle tip and ensure uniform temperature distribution. Both simulation and empirical printing experiments confirm the efficacy of thermal insulators in enhancing bioprinting fidelity and efficiency. This research contributes to the advancement of bioprinting technology by optimizing printhead design, with implications for improving the quality of bioprinted tissues and organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.