Evidence map›Paper›PMID 39203489›Full record

ArticleMicroorganisms2024

Nisin, a Probiotic Bacteriocin, Modulates the Inflammatory and Microbiome Changes in Female Reproductive Organs Mediated by Polymicrobial Periodontal Infection.

Changchang Ye, Chuanjiang Zhao, Ryutaro Kuraji, Li Gao, Hélène Rangé, Pachiyappan Kamarajan, Allan Radaic, Yvonne L Kapila

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Changchang YeOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4713-0809
Chuanjiang ZhaoOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.
Ryutaro KurajiOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-7900-3604
Li GaoOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.
Hélène RangéOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-4761-0805
Pachiyappan KamarajanOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.
Allan RadaicOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-0899-9061
Yvonne L KapilaOrofacial Sciences Department, School of Dentistry, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-1330-0654

Funding

Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
National Natural Science Foundation of China 81600875NIDCR NIH HHS R01 DE025225NIH HHS R01 DE025225
6 · The paper itself

Abstract

Periodontitis-related oral microbial dysbiosis is thought to contribute to adverse pregnancy outcomes (APOs), infertility, and female reproductive inflammation. Since probiotics can modulate periodontitis and oral microbiome dysbiosis, this study examined the effects of a probiotic bacteriocin, nisin, in modulating the reproductive microbiome and inflammation triggered by periodontitis. A total of 24 eight-week-old BALB/cByJ female mice were randomly divided into four treatment groups (control, infection, nisin, and infection+nisin group), with 6 mice per group. A polymicrobial (

Indexed as

antimicrobial therapynisinoral microbiomeperiodontal diseasereproductive tract microbiome

Identifiers

PMID39203489
PMCPMC11357294

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.