Evidence map›Paper›PMID 39203451›Full record

ArticleMicroorganisms2024

The Effects of Aspirin Intervention on Inflammation-Associated Lingual Bacteria: A Pilot Study from a Randomized Clinical Trial.

Guillaume C Onyeaghala, Shweta Sharma, Mosunmoluwa Oyenuga, Christopher M Staley, Ginger L Milne, Ryan T Demmer, Aasma Shaukat, Bharat Thyagarajan, Robert J Straka, Timothy R Church and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guillaume C OnyeaghalaDivision of Nephrology, Hennepin Healthcare, University of Minnesota, Minneapolis, MN 55415, USA.ORCID 0000-0001-8090-5640
Shweta SharmaDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0003-2859-9115
Mosunmoluwa OyenugaDepartment of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, St. Louis, MO 63117, USA.
Christopher M StaleyDepartment of Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2309-0083
Ginger L MilneDepartment of Medicine, Vanderbilt School of Medicine, Nashville, TN 37232, USA.
Ryan T DemmerMayo Clinic College of Medicine & Sciences, Rochester, MN 55905, USA.
Aasma ShaukatDepartment of Population Health, New York University Grossman School of Medicine, New York University, New York, NY 10016, USA.
Bharat ThyagarajanDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-6968-6985
Robert J StrakaDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9541-7823
Timothy R ChurchMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-3292-5035
Anna E PrizmentDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5924-6871

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
National Institutes of Health's National Center for Advancing Translational Sciences UL1TR002494NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

Several bacterial taxa enriched in inflammatory bowel diseases and colorectal cancer (CRC) are found in the oral cavity. We conducted a pilot study nested within a six-week aspirin intervention in a randomized placebo-controlled trial to test their response to aspirin intervention. Fifty healthy subjects, 50-75 years old, were randomized to receive 325 mg aspirin (n = 30) or placebo (n = 20) orally once daily for six weeks. Oral tongue swabs were collected at baseline and week six. We estimated the association between aspirin use and the temporal changes in the relative abundance of pre-specified genus level taxa from pre- to post-treatment. The temporal change in relative abundance differed for eight genus level taxa between the aspirin and placebo groups. In the aspirin group, there were significant increases in the relative abundances of

Indexed as

aspirincolorectal canceroral microbiomeperiodontitis

Identifiers

PMID39203451
PMCPMC11357305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.