Evidence map›Paper›PMID 39203408›Full record

ReviewMicroorganisms2024

The Impact of Gestational Diabetes Mellitus (GDM) on the Development and Composition of the Neonatal Gut Microbiota: A Systematic Review.

Rozeta Sokou, Eirini Moschari, Alexia Eleftheria Palioura, Aikaterini-Pothiti Palioura, Alexandra Mpakosi, Theodoula Adamakidou, Eugenia Vlachou, Martha Theodoraki, Nicoletta Iacovidou, Athanasios N Tsartsalis

Abstract readReview
In one paragraph

Review in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rozeta SokouNeonatal Intensive Care Unit, General Hospital of Nikea "Agios Panteleimon", 18454 Piraeus, Greece.ORCID 0000-0002-9972-8901
Eirini MoschariNeonatal Intensive Care Unit, General Hospital of Nikea "Agios Panteleimon", 18454 Piraeus, Greece.
Alexia Eleftheria PaliouraNeonatal Intensive Care Unit, General Hospital of Nikea "Agios Panteleimon", 18454 Piraeus, Greece.
Aikaterini-Pothiti PaliouraNeonatal Intensive Care Unit, General Hospital of Nikea "Agios Panteleimon", 18454 Piraeus, Greece.
Alexandra MpakosiDepartment of Microbiology, General Hospital of Nikea "Agios Panteleimon", 18454 Piraeus, Greece.ORCID 0000-0002-9833-8477
Theodoula AdamakidouDepartment of Nursing, School of Health Sciences, University of West Attica, Ag. Spydironos 28, 12243 Athens, Greece.ORCID 0000-0002-6025-8260
Eugenia VlachouDepartment of Nursing, School of Health Sciences, University of West Attica, Ag. Spydironos 28, 12243 Athens, Greece.
Martha TheodorakiNeonatal Intensive Care Unit, General Hospital of Nikea "Agios Panteleimon", 18454 Piraeus, Greece.
Nicoletta IacovidouNeonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece.ORCID 0000-0001-8021-6191
Athanasios N TsartsalisDepartment of Endocrinology Diabetes and Metabolism, Naval Hospital of Athens, Dinokratous 70, 11521 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is an important health issue, as it is connected with adverse effects to the mother as well as the fetus. A factor of essence for the pathology of this disorder is the gut microbiota, which seems to have an impact on the development and course of GDM. The role of the gut microbiota on maternal reproductive health and all the changes that happen during pregnancy as well as during the neonatal period is of high interest. The correct establishment and maturation of the gut microbiota is of high importance for the development of basic biological systems. The aim of this study is to provide a systematic review of the literature on the effect of GDM on the gut microbiota of neonates, as well as possible links to morbidity and mortality of neonates born to mothers with GDM. Systematic research took place in databases including PubMed and Scopus until June 2024. Data that involved demographics, methodology, and changes to the microbiota were derived and divided based on patients with exposure to or with GDM. The research conducted on online databases revealed 316 studies, of which only 16 met all the criteria and were included in this review. Research from the studies showed great heterogeneity and varying findings at the level of changes in α and β diversity and enrichment or depletion in phylum, gene, species, and operational taxonomic units in the neonatal gut microbiota of infants born to mothers with GDM. The ways in which the microbiota of neonates and infants are altered due to GDM remain largely unclear and require further investigation. Future studies are needed to explore and clarify these mechanisms.

Indexed as

gestational diabetesmicrobiotaneonatal morbidityneonatal mortality

Identifiers

PMID39203408
PMCPMC11356352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.