Evidence map›Paper›PMID 39202943›Full record

ReviewMolecules (Basel, Switzerland)2024

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction.

Marcos Díaz-Fernández, Manuel Algarra, Saturnino Calvo-Losada, José-Joaquín Quirante, Francisco Sarabia, María-Soledad Pino-González

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Inverting the Conventional Site Selectivity of Cross-Coupling of 2,4-Dichloropyrimidines.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcos Díaz-FernándezDepartment of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.ORCID 0000-0003-3068-301X
Manuel AlgarraDepartment of Science, INAMAT2-Institute for Advanced Materials and Mathematics, Public University of Navarra, 31006 Pamplona, Spain.ORCID 0000-0003-2410-8430
Saturnino Calvo-LosadaDepartment of Physical Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.ORCID 0000-0001-8247-7352
José-Joaquín QuiranteDepartment of Physical Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.ORCID 0000-0003-1040-989X
Francisco SarabiaDepartment of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.ORCID 0000-0002-5149-3576
María-Soledad Pino-GonzálezDepartment of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.ORCID 0000-0001-7711-6771

Funding

Ministry of Science and Innovation RTI2018-098296-BI00 and PID2021-122613OB-I00
6 · The paper itself

Abstract

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.

Indexed as

asymmetricBiginelli reactionenantioselectivemulticomponent reactionsN-heterocyclespyrimidines

Identifiers

PMID39202943
PMCPMC11357475

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.