Evidence map›Paper›PMID 39202934›Full record

ArticleMolecules (Basel, Switzerland)2024

An Investigation of Novel Series of 2-Thioxo-1,3-dithiol-carboxamides as Potential Antispasmodic Agents: Design, Synthesis via Coupling Reactions, Density Functional Theory Calculations, and Molecular Docking.

Riham Sghyar, Mouad Lahyaoui, Noura Aflak, Oussama Moussaoui, Alae Chda, Rachid Bencheikh, El Mestafa El Hadrami, Nada Kheira Sebbar, Ashwag S Alanazi, Mohamed Hefnawy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Linking phytochemistry to bioactivity:Frontiers in chemistry · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riham SghyarLaboratory of Applied Organic Chemistry, Faculty of Science and Techniques, Sidi Mohamed Ben Abdellah University, Routed 'Imouzzer, B.P. 2202, Fez 30050, Morocco.
Mouad LahyaouiLaboratory of Applied Organic Chemistry, Faculty of Science and Techniques, Sidi Mohamed Ben Abdellah University, Routed 'Imouzzer, B.P. 2202, Fez 30050, Morocco.ORCID 0000-0002-8068-7177
Noura AflakDepartment of Chemistry, Faculty of Science, University Ibn Zohr, Agadir 80000, Morocco.ORCID 0000-0002-6396-2114
Oussama MoussaouiLaboratory of Applied Organic Chemistry, Faculty of Science and Techniques, Sidi Mohamed Ben Abdellah University, Routed 'Imouzzer, B.P. 2202, Fez 30050, Morocco.
Alae ChdaInstitut Supérieur Des Professions Infirmières Et Techniques de Santé, Rabat 60000, Morocco.
Rachid BencheikhMicrobial Biotechnology and Bioactive Molecules Laboratory, FST, USMBA, B.P. 2202, Fez 30050, Morocco.ORCID 0000-0001-6341-6677
El Mestafa El HadramiLaboratory of Applied Organic Chemistry, Faculty of Science and Techniques, Sidi Mohamed Ben Abdellah University, Routed 'Imouzzer, B.P. 2202, Fez 30050, Morocco.ORCID 0000-0002-2212-8510
Nada Kheira SebbarApplied Chemistry and Environment Laboratory, Applied Bioorganic Chemistry Team, Faculty of Science, Ibn Zohr University, Agadir 80000, Morocco.
Ashwag S AlanaziDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0003-1042-8126
Mohamed HefnawyDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Funding

Princess Nourah bint Abdulrahman University researcher PNURSP2024R342the Researchers Supporting Project RSPD2024R754
6 · The paper itself

Abstract

This study reports the synthesis of 2-thioxo-1,3-dithiol-carboxamides (

Indexed as

Molecular Docking SimulationParasympatholyticsAnimalsDensity Functional TheoryDrug DesignJejunumMolecular StructureStructure-Activity RelationshipParasympatholytics2-thioxo-1,3-dithiol-carboxamides (TDTCAs)amino acidsantispasmodic activityDFT Calculationsmolecular dockingpeptidic coupling

Identifiers

PMID39202934
PMCPMC11356991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.