Evidence map›Paper›PMID 39202923›Full record

ReviewMolecules (Basel, Switzerland)2024

Acyl-1,4-Dihydropyridines: Universal Acylation Reagents for Organic Synthesis.

Karthikeyan Manoharan, Bartosz Bieszczad

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karthikeyan ManoharanCentre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
Bartosz BieszczadCentre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-9503-0792

Funding

SFI-IRC Pathway Programme 22/PATH-S/10609.
6 · The paper itself

Abstract

Acyl-1,4-dihydropyridines have recently emerged as universal acylation reagents. These easy-to-make and bench-stable NADH biomimetics play the dual role of single-electron reductants and sources of acyl radicals. This review article discusses applications of acyl-1,4-dihydropyridines in organic synthesis since their introduction in 2019. Acyl-1,4-dihydropyridines, activated by photochemical, thermal or electrochemical methods, have been successfully applied as radical sources in multiple diverse organic transformations such as acyl radical addition to olefins, alkynes, imines and other acceptors, as well as in the late-stage functionalisation of natural products and APIs. Release of acyl radicals and an electron can be performed under mild conditions-in green solvents, under air and sunlight, and without the use of photocatalysts, photosensitizers or external oxidants-which makes them ideal reagents for organic chemists.

Indexed as

acylationacyl radicalsdihydropyridinesorganic synthesis

Identifiers

PMID39202923
PMCPMC11356872

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.