Asymmetric Hydrogenation of Ketones by Simple Alkane-Diyl-Based Ir(P,N,O) Catalysts: A Comparative Study.

Zsófia Császár, Mária Guóth, Margit Kovács, Attila C Bényei, József Bakos, Gergely Farkas

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zsófia CsászárResearch Group of Organic Chemistry-Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary.

Mária GuóthResearch Group of Organic Chemistry-Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary.

Margit KovácsNMR Laboratory, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary.ORCID 0009-0004-4171-9182

Attila C BényeiDepartment of Physical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.ORCID 0000-0002-0617-6264

József BakosResearch Group of Organic Chemistry-Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary.ORCID 0000-0003-3502-6473

Gergely FarkasResearch Group of Organic Chemistry-Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary.ORCID 0000-0002-4119-0918

Funding

National Research, Development and Innovation Fund TKP2021-NKTA-21Recovery and Resilience Facility of the European Union RRF-2.3.1-21-2022-00009

6 · The paper itself

Abstract

The development of new chiral ligands with simple and modular structure represents a challenging direction in the design of efficient homogeneous transition metal catalysts. Herein, we report on the asymmetric hydrogenation of prochiral ketones catalyzed by the iridium complexes of simple alkane-diyl-based P,N,O-type chiral ligands with a highly modular structure. The role of (i) the P-N and N-O backbone in the potentially tridentate ligands, (ii) the number, position and relative configuration of their stereogenic elements and (iii) the effect of their NH and OH subunits on the activity and enantioselectivity of the catalytic reactions are studied. The systematic variation in the ligand structure and the comparative catalytic experiments shed light on different mechanistic aspects of the iridium-catalyzed reaction. The catalysts containing the simple alkane-diyl-based ligands with central chirality provided high enantioselectivities (up to 98%

Indexed as

asymmetric hydrogenationiridiumphosphine–amine–alcoholphosphine–amine–etherP,N,O ligandprochiral ketone

Identifiers

PMID39202822

DOI10.3390/molecules29163743

PMCPMC11357652

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.