Evidence map›Paper›PMID 39202808›Full record

ArticleMolecules (Basel, Switzerland)2024

Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation.

Guoji Zhang, Liqin Wang, Yaxuan Qu, Shilun Mo, Xiaoying Sun, Kewei Wang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guoji ZhangDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, 1 Ningde Road, Qingdao 266073, China.
Liqin WangDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University Medical College, 1 Ningde Road, Qingdao 266073, China.
Yaxuan QuDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, 1 Ningde Road, Qingdao 266073, China.
Shilun MoDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University Medical College, 1 Ningde Road, Qingdao 266073, China.
Xiaoying SunDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University Medical College, 1 Ningde Road, Qingdao 266073, China.ORCID 0000-0003-1922-973X
Kewei WangDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, 1 Ningde Road, Qingdao 266073, China.ORCID 0000-0001-7023-9998

Funding

Ministry of Science and Technology of China 2018ZX09711001-004-006National Natural Science Foundation of China 81903734; 81973299Natural Science Foundation of Shandong Province ZR2023MH081
6 · The paper itself

Abstract

Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases. However, the molecular mechanism underlying the effects of the CA remains largely unknown. Here, we report that CA and its two analogues, caffeic acid phenethyl ester (CAPE) and caffeic acid methyl caffeate (CAMC), inhibit TRPV3 currents in their concentration- and structure-dependent manners with IC

Indexed as

Caffeic AcidsMolecular Docking SimulationTRPV Cation ChannelsAnimalsAnti-Inflammatory AgentsCymenesHEK293 CellsHumansInflammationMiceSkinAnti-Inflammatory Agentscaffeic acidCaffeic AcidscarvacrolCymenesTRPV3 protein, humanTrpv3 protein, mouseTRPV Cation Channelscaffeic acidcaffeoyl analoguesskin inflammationTRPV3

Identifiers

PMID39202808
PMCPMC11357638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.