ArticleLife (Basel, Switzerland)2024
Exploring the Core Formose Cycle: Catalysis and Competition.
Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Strands in a Web: Free Energies of Select Prebiotic Reactions with Sugars, Nitriles and Azoles.Life (Basel, Switzerland) · 2026Article
- The Formose Reaction with SOLife (Basel, Switzerland) · 2026Article
- Sugars to Acids via Thioesters: A Computational Study.Life (Basel, Switzerland) · 2025Article
- The second wave of formose research.BBA advances · 2025Article
- Sulfur Analogs of the Core Formose Cycle: A Free Energy Map.Life (Basel, Switzerland) · 2024Article
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Authors and funding
2 authors.
Funding
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Abstract
The core autocatalytic cycle of the formose reaction may be enhanced or eroded by the presence of simple molecules at life's origin. Utilizing quantum chemistry, we calculate the thermodynamics and kinetics of reactions both within the core cycle and those that deplete the reactants and intermediates, such as the Cannizzaro reaction. We find that via disproportionation of aldehydes into carboxylic acids and alcohols, the Cannizzaro reaction furnishes simple catalysts for a variety of reactions. We also find that ammonia can catalyze both in-cycle and Cannizzaro reactions while hydrogen sulfide does not; both, however, play a role in sequestering reactants and intermediates in the web of potential reactions.
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