Evidence map›Paper›PMID 39202462›Full record

ArticleGenes2024

Identification of Nonsynonymous SNPs in Immune-Related Genes Associated with Pneumonia Severity in Pigs.

Hiroki Shinkai, Kasumi Suzuki, Tomohito Itoh, Gou Yoshioka, Takato Takenouchi, Haruki Kitazawa, Hirohide Uenishi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroki ShinkaiNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba 305-0856, Japan.
Kasumi SuzukiSwine and Poultry Research Department, Gifu Prefectural Livestock Research Institute, Seki 501-3924, Japan.ORCID 0000-0001-7917-7842
Tomohito ItohMaebashi Institute of Animal Science, Livestock Improvement Association of Japan, Maebashi 371-0121, Japan.
Gou YoshiokaSwine and Poultry Research Department, Gifu Prefectural Livestock Research Institute, Seki 501-3924, Japan.
Takato TakenouchiInstitute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), Tsukuba 305-8634, Japan.
Haruki KitazawaFood and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Sciences, Tohoku University, Sendai 980-8572, Japan.ORCID 0000-0003-4586-5553
Hirohide UenishiInstitute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), Tsukuba 305-8634, Japan.ORCID 0000-0002-3899-9580

Funding

Bio-oriented Technology Research Advancement Institution JPJ007097/01002AB2Japan Racing Association R06-46
6 · The paper itself

Abstract

We previously showed that several polymorphisms in genes encoding pattern recognition receptors that cause amino acid substitutions alter pathogen recognition ability and disease susceptibility in pigs. In this study, we expanded our analysis to a wide range of immune-related genes and investigated polymorphism distribution and its influence on pneumonia in multiple commercial pig populations. Among the polymorphisms in 42 genes causing 634 amino acid substitutions extracted from the swine genome database, 80 in 24 genes were found to have a minor allele frequency of at least 10% in Japanese breeding stock pigs via targeted resequencing. Of these, 62 single nucleotide polymorphisms (SNPs) in 23 genes were successfully genotyped in 862 pigs belonging to four populations with data on pneumonia severity. Association analysis using a generalized linear mixed model revealed that 12 SNPs in nine genes were associated with pneumonia severity. In particular, SNPs in the cellular receptor for immunoglobulin G

Indexed as

PneumoniaPolymorphism, Single NucleotideSwine DiseasesAllelesAnimalsFemaleGenotypeMaleReceptors, Pattern RecognitionSeverity of Illness IndexSwineReceptors, Pattern Recognitiondisease resistancemycoplasmal pneumonia of swinepattern recognition receptorsporcine pleuropneumoniasingle nucleotide polymorphismswine

Identifiers

PMID39202462
PMCPMC11353625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.