Evidence map›Paper›PMID 39202366›Full record

ArticleGenes2024

Genotype-by-Environment Interactions in Nonalcoholic Fatty Liver Disease and Chronic Illness among Mexican Americans: The Role of Acculturation Stress.

Eron G Manusov, Vincent P Diego, Marcio Almeida, David Ortiz, Joanne E Curran, Jacob Galan, Ana C Leandro, Sandra Laston, John Blangero, Sarah Williams-Blangero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eron G ManusovDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0002-6052-1823
Vincent P DiegoDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0009-0008-3735-6912
Marcio AlmeidaDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.
David OrtizSchool of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Joanne E CurranDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0002-6898-155X
Jacob GalanDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0003-3304-0474
Ana C LeandroDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0002-7640-3469
Sandra LastonDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0001-5928-7702
John BlangeroDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0001-6250-5723
Sarah Williams-BlangeroDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.

Funding

Workforce Development CoreU54HG013247 · NHGRI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI John Blangero · 2023 to 2026
$10.5M
Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD RiskR01HL113323 · NHLBI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BLANGERO, JOHN, CURRAN, JOANNE E. · 2012 to 2016
$8.2M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Identification of the Exposome in Fatty Liver Disease in Mexican American Families Using Genetic CorrectionR01MD012564 · NIMHD · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BLANGERO, JOHN, CLARKE, GEOFFREY DAVID · 2018 to 2022
$3.7M
Knapp Community Care Foundation 00000NHGRI NIH HHS U54 HG013247NHLBI NIH HHS R01 HL113323NIBIB NIH HHS R01 EB015611NIMHD NIH HHS R01 MD012564
6 · The paper itself

Abstract

This study examines the complex interplay of genetic and environmental interactions that shape chronic illness risk. Evidence is mounting for the role of genetic expression and the immune response in the pathogenesis of chronic disease. In the Rio Grande Valley of south Texas, where 90% of the population is Mexican American, chronic illnesses (including obesity, diabetes, nonalcoholic liver disease, and depression) are reaching epidemic proportions. This study leverages an ongoing family study of the genetic determinants of risk for obesity, diabetes, hypertension, hyperlipidemia, and depression in a Mexican American population. Data collected included blood pressure, BMI, hepatic transaminases, HbA1c, depression (BDI-II), acculturation/marginalization (ARSMA-II), and liver health as assessed by elastography. Heritability and genotype-by-environment (G×E) interactions were analyzed, focusing on the marginalization/separation measure of the ARSMA-II. Significant heritabilities were found for traits such as HbA1c (h

Indexed as

AcculturationGene-Environment InteractionMexican AmericansNon-alcoholic Fatty Liver DiseaseAdultChronic DiseaseFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedObesityStress, PsychologicalTexasacculturation stressG×EmarginalizationMexican AmericansNAFLD

Identifiers

PMID39202366
PMCPMC11353877

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.