ReviewDiagnostics (Basel, Switzerland)2024
Line-Field Confocal Optical Coherence Tomography: A New Skin Imaging Technique Reproducing a "Virtual Biopsy" with Evolving Clinical Applications in Dermatology.
Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- 3D photogrammetry quantifies the size of basal cell carcinoma lesions with submillimeter accuracy: high correlation with lesion response to photodynamic therapy.Journal of biomedical optics · 2025Trial
- Solid Hydrogel Couplants for Skin Superficial Blood Flow Imaging With Super-Resolution Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- LC-OCT for Cutaneous Lupus Erythematosus: Characterization Across Disease Subtypes and Differentiation From Rosacea.Experimental dermatology · 2026Observational
- Non-invasive characterization of the relationship between skin microrelief and dermal-epidermal junction topography using line-field confocal optical coherence tomography (LC-OCT).Scientific reports · 2026Article
- In Vivo Microscopic Features of Acne vulgaris Revealed via LC-OCT.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
- Enhanced diagnosis of terra firma-forme dermatosis by dermoscopy and line-field confocal optical coherence tomografphy.JAAD case reports · 2026Article
- [Use of modern imaging in dermatosurgery].Dermatologie (Heidelberg, Germany) · 2025Review
- Cutting-edge insights: line-field confocal optical coherence tomography and 5% cyclosporine for early lichen sclerosus treatment.Dermatology reports · 2025Article
- [Line-field confocal optical coherence tomography in keratinocyte cancer and margin delineation in basal cell carcinoma].Dermatologie (Heidelberg, Germany) · 2025Review
- Non-Invasive Imaging in Post-Radiotherapy Monitoring of Non-Melanoma Skin Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Real-Time, Noninvasive Diagnosis of Bullous Pemphigoid: Diagnostic Performance of Line-Field Confocal Optical Coherence Tomography.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Article
- Reflectance Confocal Microscopy and LC-OCT for Noninvasive Evaluation of Clonal Seborrheic Keratosis in Dark Skin Individuals.Dermatology practical & conceptual · 2025Article
- High-Resolution Imaging of Bullous and Hemorrhagic Lichen Sclerosus Using LC-OCT.Dermatology practical & conceptual · 2025Article
- High-frequency quantitative ultrasound in characterizing human skin aging: an exploration of the non-modeling and modeling approaches.Quantitative imaging in medicine and surgery · 2025Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Review
- Locally advanced basal cell carcinoma treated with sonidegib:Skin health and disease · 2025Article
- Validity and Advantages of Three-Dimensional High-Frequency Ultrasound in Dermatological Evaluation.Diagnostics (Basel, Switzerland) · 2025Article
- Precision measurement of stratum corneum thickness in OCT images using variational autoencoders and advanced DSP techniques.Frontiers in bioengineering and biotechnology · 2025Review
- It Looks Like a Zebra but Is Not: [Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLine-field confocal optical coherence tomography is a novel technology able to reproduce a "virtual biopsy" of the skin. The aim of this review is to explore the application of line-field confocal optical coherence tomography (LC-OCT) in various skin diseases, covering skin cancers, inflammatory and infectious skin diseases, genetic diseases, cosmetic procedures, and less common disorders.
methodsStudy selection was conducted based on LC-OCT and using pertinent MeSh terms, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines from inception to March 2024; to evaluate the quality and risk of bias of studies, Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used.
resultsthe search retrieved 154 papers according to the selection criteria; after removing publications by one or more of the exclusion criteria, a total of 96 studies were found to be suitable for the analysis.
conclusionsIncreasing evidence supports the use of LC-OCT as an adjunctive diagnostic tool for the in vivo diagnosis of a variety of skin tumors. As this device can be considered a "bridge" between dermoscopy and histopathology, widening applications in numerous fields of clinical dermatology, including inflammatory skin disease treatment, presurgical mapping, cosmetic procedures, and monitoring of non-invasive therapies, have been explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.