Evidence map›Paper›PMID 39202302›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Evaluation of Open-Source Ciliary Analysis Software in Primary Ciliary Dyskinesia: A Comparative Assessment.

Zachary J Demetriou, José Muñiz-Hernández, Gabriel Rosario-Ortiz, Frances M Quiñones, Gabriel Gonzalez-Diaz, Marcos J Ramos-Benitez, Ricardo A Mosquera, Wilfredo De Jesús-Rojas

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zachary J DemetriouDepartment of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA.
José Muñiz-HernándezSan Juan Bautista School of Medicine, Caguas, PR 00725, USA.ORCID 0009-0000-7958-1562
Gabriel Rosario-OrtizDepartment of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA.
Frances M QuiñonesDepartment of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA.
Gabriel Gonzalez-DiazDepartment of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA.ORCID 0009-0001-1403-1196
Marcos J Ramos-BenitezDepartment of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA.
Ricardo A MosqueraDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Wilfredo De Jesús-RojasDepartment of Pediatrics and Basic Science, Ponce Health Sciences University, Ponce, PR 00716, USA.ORCID 0000-0002-6133-3517

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
The Role of Midbrain to Prelimbic Cortex Glutamatergic projections in Stress-induced Drug SeekingU54MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI Emmanuel Antonio Cruz, Kenira J Thompson · 2019 to 2026
$35.9M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI WOJNA, VALERIE · 2020 to 2024
$17.7M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI NOEL, RICHARD J. · 2012 to 2018
$15.9M
Hispanic Clinical and Translational Research Education and Career Development ProgramR25MD007607 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Karen G. Martinez Gonzalez, Barbara Segarra-Vazquez · 2012 to 2026
$7.4M
HCTRECD: National Institute on Minority Health and Health Disparities R25MD007607NIGMS NIH HHS P20 GM103475NIMHD NIH HHS G12 MD007579NIMHD NIH HHS R25 MD007607NIMHD NIH HHS U54 MD007579RCMI Specialized Center for Health Disparities at PHSU MD007579
6 · The paper itself

Abstract

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by alterations in motile cilia function. The diagnosis of PCD is challenging due to the lack of standardized methods in clinical practice. High-speed video microscopy analysis (HSVA) directly evaluates ciliary beat frequency (CBF) in PCD. Recently, open-source ciliary analysis software applications have shown promise in measuring CBF accurately. However, there is limited knowledge about the performance of different software applications, creating a gap in understanding their comparative effectiveness in measuring CBF in PCD. We compared two open-source software applications, CiliarMove (v219) and Cilialyzer (v1.2.1-b3098cb), against the manual count method. We used high-speed videos of nasal ciliary brush samples from PCD

Indexed as

CilialyzerCiliarMoveciliary beat frequencyhigh-speed video microscopy analysisprimary ciliary dyskinesia

Identifiers

PMID39202302
PMCPMC11354199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.