ArticleDiagnostics (Basel, Switzerland)2024
The Usefulness of Line-Field Confocal Optical Coherence Tomography in Monitoring Epidermal Changes in Atopic Dermatitis in Response to Treatment: A Pilot Study.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Line-field Confocal Optical Coherence Tomography Detects Subclinical Disease Activity in Atopic Dermatitis during Treatment with Pimecrolimus: An Intrapatient, Controlled Study.Acta dermato-venereologica · 2026Article
- From Lab to Workplace: Efficacy of Skin Protection Creams Against Hydrophobic Working Materials.Journal of clinical medicine · 2025Review
- [Line-field confocal optical coherence tomography in keratinocyte cancer and margin delineation in basal cell carcinoma].Dermatologie (Heidelberg, Germany) · 2025Review
- Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics.Journal of translational medicine · 2025Article
- Three-Dimensional Curved Workflow-Based Optical Coherence Tomography Angiography for Enhancing Atopic Dermatitis Theranostics.Research (Washington, D.C.) · 2025Article
- Precision measurement of stratum corneum thickness in OCT images using variational autoencoders and advanced DSP techniques.Frontiers in bioengineering and biotechnology · 2025Review
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7 authors.
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Abstract
backgroundAtopic dermatitis (AD) is the most common chronic inflammatory skin disease. Due to its high prevalence, considerable morbidity, and chronicity, there is a need for the accurate in vivo evaluation of treatment efficacy. Line-field confocal optical coherence tomography (LC-OCT) is a new emerging imaging technique able to perform a non-invasive, real-time examination of the epidermis and the upper dermis. LC-OCT may represent a promising tool in the diagnosis and treatment follow-up of chronic eczematous skin diseases with barrier defects.
objectivesWe aimed to investigate the role of LC-OCT in the non-invasive monitoring of the treatment effect on five patients with severe atopic dermatitis during dupilumab treatment. MATERIALS AND
methodsLC-OCT imaging was performed on five patients (three women and two men) aged between 14 and 85 years old at the baseline and at 2, 4, and 6 weeks of treatment with dupilumab. The LC-OCT scans were performed at two sites, the lesional skin in the antecubital fossa and the extensor part of the arm, considered a control site on each patient for comparison. The captured images were later evaluated. Descriptive statistics and a
resultsThe LC-OCT imaging was able to detect the difference in stratum corneum (SC) thickness and quality and epidermal thickness (ET) and the changes before and after treatment with high accuracy. The main findings include a significant reduction in the epidermal and stratum corneum thickness and decreased epidermal spongiosis and inflammation, with better quality of the stratum corneum indicating restoration of its tightness at both lesional and control sites.
conclusionsThis study demonstrates that clinical improvement of affected and unaffected atopic skin under dupilumab treatment correlates with the LC-OCT findings. LC-OCT represents a novel, non-invasive tool examining the in vivo skin barrier and inflammation and can help to monitor the treatment efficacy among patients with atopic dermatitis in daily practice.
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