Evidence map›Paper›PMID 39202207›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Club Cell Secretory Protein-16 (CC16) as a Prognostic Biomarker for COVID-19 and H1N1 Viral Infections.

Shane Moore, Keerthana Gopichandran, Elizabeth Sevier, Siddhika Gamare, Sultan Almuntashiri, Gustavo Ramírez, Nora Regino, Luis Jiménez-Alvarez, Alfredo Cruz-Lagunas, Tatiana S Rodriguez-Reyna and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shane MooreDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0009-0003-4597-6314
Keerthana GopichandranDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Elizabeth SevierDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Siddhika GamareDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Sultan AlmuntashiriDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Gustavo RamírezLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Mexico City 14080, Mexico.ORCID 0000-0001-5157-0677
Nora ReginoLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Mexico City 14080, Mexico.
Luis Jiménez-AlvarezLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Mexico City 14080, Mexico.
Alfredo Cruz-LagunasLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Mexico City 14080, Mexico.
Tatiana S Rodriguez-ReynaDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico City 14080, Mexico.
Joaquin ZuñigaLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Mexico City 14080, Mexico.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xiaoyun WangDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0002-9900-740X
Duo ZhangDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-0361-4174

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
Lincenc1 regulates the lipopolysaccharide-induced inflammatory response in macrophagesR00HL141685 · NHLBI · UNIVERSITY OF GEORGIA · PI ZHANG, DUO · 2020 to 2022
$743k
The Function and Potential Application of Extracellular Vesicle Derived Clara Cell Protein 16 in Gram-negative Bacterial PneumoniaR56HL163607 · NHLBI · UNIVERSITY OF GEORGIA · PI ZHANG, DUO · 2023 to 2023
$501k
MMP-8 Deficiency Improves Host Responses to Influenza Viral InfectionsF32HL147437 · NHLBI · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2019 to 2021
$205k
Mechanistic Insights of TIMP-1 in Influenza Virus InfectionR03AI169063 · NIAID · UNIVERSITY OF GEORGIA · PI WANG, XIAOYUN · 2022 to 2023
$151k
NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NHLBI NIH HHS F32 HL147437NHLBI NIH HHS R00 HL141685NHLBI NIH HHS R56 HL163607NIAID NIH HHS R03 AI169063NIA NIH HHS U54 AG062334NIH HHS R03AI169063; KL2TR002381; UL1TR002378; R00HL141685; R56HL163607
6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and H1N1 viruses are inflammatory lung pathogens that can lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). ALI/ARDS are still life-threatening diseases in critically ill patients with 30-40% mortality in the last decade. Currently, there are no laboratory tests for the early diagnosis or prognosis of ALI/ARDS. Club cell secretory protein (CC16) has been investigated as a potential biomarker of lung epithelial damage in various lung diseases. In this study, we evaluated whether plasma CC16 reflects the severity of COVID-19 and H1N1 infections. The plasma CC16 levels showed no significant differences between H1N1 and COVID-19 groups (

Indexed as

acute lung injuryacute respiratory distress syndromehospital stayinfluenza A virusuteroglobin

Identifiers

PMID39202207
PMCPMC11353392

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.