Evidence map›Paper›PMID 39201987›Full record

ArticleJournal of personalized medicine2024

Cognitive, Neuropsychological and Biological Effects of Oxygen-Ozone Therapy on Frailty: A Study Protocol for a 5-Week, Randomized, Placebo-Controlled Trial.

Catia Scassellati, Cristian Bonvicini, Miriam Ciani, Roberta Zanardini, Evita Tomasoni, Valentina Saletti, Ilaria Passeggia, Monica Almici, Ilaria Pagnoni, Antonio Carlo Galoforo and 4 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Catia ScassellatiBiological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Cristian BonviciniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-1577-2823
Miriam CianiDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Roberta ZanardiniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0001-7727-0584
Evita TomasoniLaboratory Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Valentina SalettiLaboratory Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Ilaria PasseggiaLaboratory Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Monica AlmiciClinical Trial Service, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-5002-4591
Ilaria PagnoniNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Antonio Carlo GaloforoOxygen-Ozone Therapy Scientific Society (SIOOT), 24020 Gorle, Italy.
Mario CostaInstitute of Neuroscience, Italian National Research Council (CNR), 56124 Pisa, Italy.ORCID 0000-0001-5821-9871
Mara D'OnofrioEuropean Brain Research Institute (EBRI) Rita Levi-Montalcini, 00161 Rome, Italy.
Antonino CattaneoLaboratory of Biology "Bio@SNS", Scuola Normale Superiore, 56124 Pisa, Italy.
Cristina GeroldiAlzheimer's Unit, Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.

Funding

Italian Ministry of Health RF-2016-02363298Italian Ministry of Health Ricerca Corrente
6 · The paper itself

Abstract

Cognitive frailty (CF) is a heterogeneous syndrome that is becoming one of the most serious health problems as the world's population age is increasing. Elucidating its biological mechanisms as well as prevention and treatments is becoming increasingly significant, particularly in view of the associated health costs. We presented the study protocol of a research project funded by the Italian Ministry of Health (grant number RF-2016-02363298) aiming to investigate the cognitive and neuropsychological effects of a 5-week treatment with therapy based on the regenerative properties of ozone (O

Indexed as

biological markerscognitive frailtyfrailtyneuropsychological markersoxygen–ozone therapyrandomized double-blind clinical trial

Identifiers

PMID39201987
PMCPMC11355685

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.