Evidence map›Paper›PMID 39201706›Full record

ReviewInternational journal of molecular sciences2024

Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations.

F Peter Guengerich, Yasuhiro Tateishi, Kevin D McCarty, Francis K Yoshimoto

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Cytochrome P450The Journal of biological chemistry · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0002-7458-3048
Yasuhiro TateishiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Kevin D McCartyDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0003-0027-9120
Francis K YoshimotoDepartment of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-2308-2999

Funding

Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3M
National Science Foundation 1937963NIGMS NIH HHS R01 GM118122NIH HHS R01 GM118122
6 · The paper itself

Abstract

Cytochrome P450 (P450) enzymes dominate steroid metabolism. In general, the simple C-hydroxylation reactions are mechanistically straightforward and are generally agreed to involve a perferryl oxygen species (formally FeO

Indexed as

Cytochrome P-450 Enzyme SystemOxidation-ReductionSteroidsAnimalsBiocatalysisCatalysisHumansCytochrome P-450 Enzyme SystemSteroidscarbon-carbon bond cleavagecholesterolcytochrome P450ferric peroxidelanosteroloxidation mechanismsprocessivitysteroid biosynthesissteroid oxidationssteroids

Identifiers

PMID39201706
PMCPMC11354347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.