Evidence map›Paper›PMID 39201700›Full record

ArticleInternational journal of molecular sciences2024

Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction.

Fredric A Holme, Camilla Huse, Xiang Yi Kong, Kaspar Broch, Lars Gullestad, Anne Kristine Anstensrud, Geir Ø Andersen, Brage H Amundsen, Ola Kleveland, Ana Quiles-Jimenez and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fredric A HolmeInstitute of Clinical Medicine, University of Oslo (UiO), 0372 Oslo, Norway.ORCID 0009-0002-6227-1992
Camilla HuseInstitute of Clinical Medicine, University of Oslo (UiO), 0372 Oslo, Norway.ORCID 0000-0002-7694-5196
Xiang Yi KongResearch Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0003-3244-344X
Kaspar BrochDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0003-4316-805X
Lars GullestadInstitute of Clinical Medicine, University of Oslo (UiO), 0372 Oslo, Norway.ORCID 0000-0002-5932-6641
Anne Kristine AnstensrudDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0003-1499-2402
Geir Ø AndersenDepartment of Cardiology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway.
Brage H AmundsenClinic of Cardiology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.
Ola KlevelandClinic of Cardiology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.
Ana Quiles-JimenezResearch Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0003-0090-589X
Sverre HolmResearch Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
Pål AukrustInstitute of Clinical Medicine, University of Oslo (UiO), 0372 Oslo, Norway.ORCID 0000-0003-0919-836X
Ingrun AlsethDepartment of Microbiology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
Bente HalvorsenInstitute of Clinical Medicine, University of Oslo (UiO), 0372 Oslo, Norway.ORCID 0000-0002-6529-6485
Tuva B DahlResearch Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0001-7818-9411

Funding

Health Authority South-Eastern Regional Health Authority 2019067 and 2018084Medical Research Program (MSRP) at the University of Oslo UiOResearch Council of Norway 271555/F20 and 283867
6 · The paper itself

Abstract

Circular (circ) RNAs are non-coding RNAs with important functions in the nervous system, cardiovascular system, and cancer. Their role in atherosclerosis and myocardial infarction (MI) remains poorly described. We aim to investigate the potential circRNAs in immune cells during atherogenesis and examine the most regulated during MI and the modulation by interleukin (IL)-6 receptor inhibition by tocilizumab. Wild-type (WT) and

Indexed as

AtherosclerosisRNA, CircularST Elevation Myocardial InfarctionAgedAnimalsAntibodies, Monoclonal, HumanizedFemaleGene Expression RegulationHumansMaleMiceMice, Inbred C57BLMiddle AgedReceptors, Interleukin-6Antibodies, Monoclonal, HumanizedReceptors, Interleukin-6RNA, CirculartocilizumabatherosclerosisCircRNASTEMItocilizumab

Identifiers

PMID39201700
PMCPMC11354517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.